• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GDNF Family Receptor Alpha-4 (GFRA4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1327360

This protein is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases.… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
GDNF family receptor alpha-4 (GFRA4), Recombinant Protein
Full Product Name
Recombinant Human GDNF family receptor alpha-4 (GFRA4)
Product Gene Name
GFRA4 recombinant protein
Product Synonym Gene Name
GFRA4
Sequence
VGGNRCVDAA EACTADARCQ RLRSEYVAQC LGRAAQGGCP RARCRRALRR FFARGPPALT HALLFCPCAG PACAERRRQT FVPSCAFSGP GPAPPSCLEP LNFCERSRVC RCARAAAGPW RGWGRGLSPA HRPPAAQASP PGLSGLVHPS AQRPRRLPAG PGRPLPARLR GPRGVPAGTA VTPNYVDNVS ARVAPWCDCG ASGNRREDCE AFRGLFTRNR CLDGAIQAFA SGWPPVLLDQ LNPQGDPEHS LLQVSSTG
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
19,216 Da
Sequence Positions
21-278aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9GZZ7
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of GFRA4 recombinant protein

Human GFRA4 Recombinant Protein – Cat# MBS1327360

Other Notes

Small volumes of GFRA4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GFRA4 purchase

MBS1327360 is a recombinant protein targeting GFRA4. Also known as Recombinant Human GDNF family receptor alpha-4 (GFRA4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for GFRA4. It may not necessarily be applicable to this product.

NCBI GI #
11545875
NCBI GeneID
64096
NCBI Accession #
NP_071422.1
UniProt Primary Accession #
Q9GZZ7
UniProt Secondary Accession #
Q5JT74; Q9H191; Q9H192
UniProt Related Accession #
Q9GZZ7
GenBank Nucleotide #
NM_022139.3
NCBI Official Full Name
GDNF family receptor alpha-4 isoform a
NCBI Official Synonym Full Names
GDNF family receptor alpha 4
NCBI Official Symbol
GFRA4
UniProt Protein Name
GDNF family receptor alpha-4
UniProt Synonym Protein Names
Persephin receptor
Protein Family
GDNF family receptor
UniProt Gene Name
GFRA4
UniProt Synonym Gene Names
GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4
NCBI Protein Information
GDNF family receptor alpha-4

NCBI Summary for GFRA4

The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for GFRA4

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

Research Articles on GFRA4

1. High GFRA4 expression is associated with Hirschsprung's Disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GFRA4 recombinant protein

 Reference Product  PubMed Publications
 GDNF recombinant protein  >14 publications with GFRA4 and GDNF
 RET recombinant protein  >12 publications with GFRA4 and RET
 ATRN recombinant protein  >2 publications with GFRA4 and ATRN
 NRTN recombinant protein  >2 publications with GFRA4 and NRTN
 PSPN recombinant protein  >2 publications with GFRA4 and PSPN
 ARTN recombinant protein  >1 publications with GFRA4 and ARTN

Pathways associated with GFRA4 recombinant protein

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram

Diseases associated with GFRA4 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with GFRA4 and Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with GFRA4 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >1 publications with GFRA4 and Disease Models, Animal
 Glioma Antibodies  >1 publications with GFRA4 and Glioma
 Kidney Diseases Antibodies  >1 publications with GFRA4 and Kidney Diseases
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000