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Toll-Like Receptor 9 (TLR9) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1328270

This protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.… More details

$1675 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Toll-like receptor 9 (Tlr9), Recombinant Protein
Full Product Name
Recombinant Mouse Toll-like receptor 9 (Tlr9), partial
Product Gene Name
Tlr9 recombinant protein
Product Synonym Gene Name
Tlr9
Sequence
LGTLPAFLPC ELKPHGLVDC NWLFLKSVPR FSAAASCSNI TRLSLISNRI HHLHNSDFVH LSNLRQLNLK WNCPPTGLSP LHFSCHMTIE PRTFLAMRTL EELNLSYNGI TTVPRLPSSL VNLSLSHTNI LVLDANSLAG LYSLRVLFMD GNCYYKNPCT GAVKVTPGAL LGLSNLTHLS LKYNNLTKVP RQLPPSLEYL LVSYNLIVKL GPEDLANLTS LRVLDVGGNC RRCDHAPNPC IECGQKSLHL HPETFHHLSH LEGLVLKDSS LHTLNSSWFQ GLVNLSVLDL SENFLYESIT HTNAFQNLTR LRKLNLSFNY RKKVSFARLH LASSFKNLVS LQELNMNGIF FRLLNKYTLR WLADLPKLHT LHLQMNFINQ AQLSIFGTFR ALRFVDLSDN RISGPSTLSE ATPEEADDAE QEELLSADPH PAPLSTPASK NFMDRCKNFK FTMDLSRNNL VTIKPEMFVN LSRLQCLSLS HNSIAQAVNG SQFLPLTNLQ VLDLSHNKLD LYHWKSFSEL PQLQALDLSY NSQPFSMKGI GHNFSFVTHL SMLQSLSLAH NDIHTRVSSH LNSNSVRFLD FSGNGMGRMW DEGGLYLHFF QGLSGLLKLD LSQNNLHILR PQNLDNLPKS LKLLSLRDNY LSFFNWTSLS FLPNLEVLDL AGNQLKALTN GTLPNGTLLQ KLDVSSNSIV SVVPAFFALA VELKEVNLSH NILKTVDRSW FGPIVMNLTV LDVRSNPLHC ACGAAFVDLL LEVQTKVPGL ANGVKCGSPG QLQGRSIFAQ DLRLCLDEVL SWD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
116,412 Da
Sequence Positions
26-818. Partial, provide the complete extracellular domain.
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9EQU3
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tlr9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tlr9 purchase

MBS1328270 is a recombinant protein targeting Tlr9. Also known as Recombinant Mouse Toll-like receptor 9 (Tlr9), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Tlr9. It may not necessarily be applicable to this product.

NCBI GI #
157057166
NCBI GeneID
81897
NCBI Accession #
NP_112455.2
UniProt Primary Accession #
Q9EQU3
UniProt Secondary Accession #
Q4L0K3; Q4L0K4; Q99MF2; Q99MQ8; F8VPN5
UniProt Related Accession #
Q9EQU3
GenBank Nucleotide #
NM_031178.2
NCBI Official Full Name
toll-like receptor 9
NCBI Official Synonym Full Names
toll-like receptor 9
NCBI Official Symbol
Tlr9
UniProt Protein Name
Toll-like receptor 9
UniProt Synonym Protein Names
CD_antigen: CD289
Protein Family
Toll-like receptor
UniProt Gene Name
Tlr9
NCBI Protein Information
toll-like receptor 9

UniProt Comments for Tlr9

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:18931679, PubMed:21402738, PubMed:14993594, PubMed:17474149, PubMed:25686612, PubMed:18820679). Plays a role in defense against systemic mouse cytomegalovirus infection (PubMed:14993594). Controls lymphocyte response to Helicobacter infection (PubMed:17474149). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production ().
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Research Articles on Tlr9

1. TLR9-driven inflammation induced a Ccr2-independent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with the peripheral accumulation of monocytes in both wild-type and Ccr2(-/-) mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Tlr9 recombinant protein

 Reference Product  PubMed Publications
 Tlr3 recombinant protein  >485 publications with Tlr9 and Tlr3
 Myd88 recombinant protein  >406 publications with Tlr9 and Myd88
 Cd40 recombinant protein  >144 publications with Tlr9 and Cd40
 Cd86 recombinant protein  >109 publications with Tlr9 and Cd86
 Unc93b1 recombinant protein  >32 publications with Tlr9 and Unc93b1
 Cnpy3 recombinant protein  >1 publications with Tlr9 and Cnpy3

Pathways associated with Tlr9 recombinant protein

 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram

Diseases associated with Tlr9 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >502 publications with Tlr9 and Inflammation
 Necrosis Antibodies  >361 publications with Tlr9 and Necrosis
 Disease Models, Animal Antibodies  >206 publications with Tlr9 and Disease Models, Animal
 Nervous System Diseases Antibodies  >95 publications with Tlr9 and Nervous System Diseases
 Hepatitis Antibodies  >75 publications with Tlr9 and Hepatitis
 Cardiovascular Diseases Antibodies  >70 publications with Tlr9 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >61 publications with Tlr9 and Kidney Diseases
 Brain Diseases Antibodies  >49 publications with Tlr9 and Brain Diseases
 Drug Toxicity Antibodies  >38 publications with Tlr9 and Drug Toxicity
 Lung Neoplasms Antibodies  >34 publications with Tlr9 and Lung Neoplasms

Organs/Tissues associated with Tlr9 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >207 publications with Tlr9 and Spleen
 Liver Antibodies  >123 publications with Tlr9 and Liver
 Lymph Node Antibodies  >103 publications with Tlr9 and Lymph Node
 Skin Antibodies  >86 publications with Tlr9 and Skin
 Thymus Antibodies  >16 publications with Tlr9 and Thymus
 Testis Antibodies  >9 publications with Tlr9 and Testis
 Mammary Gland Antibodies  >2 publications with Tlr9 and Mammary Gland
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