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A Disintegrin and Metalloproteinase with Thrombospondin Motifs 12 (ADAMTS12) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1329749

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a… More details

$1420 / 0.5 mg (E-Coli) +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
A disintegrin and metalloproteinase with thrombospondin motifs 12 (Adamts12), Recombinant Protein
Full Product Name
Recombinant Mouse A disintegrin and metalloproteinase with thrombospondin motifs 12 (Adamts12) , partial
Product Gene Name
Adamts12 recombinant protein
Product Synonym Gene Name
Adamts12
Sequence
PICGLKDSLD NSVKQELQRE KWERKTLRSR SLSRRSISKE RWVETLVVAD TKTVEYHGSE NVESYILTIM NMVTGLFHSP SIGNLVHIVV VRLILLEEEE QGLKIVHHAE KTLSSFCKWQ KSINPKSDLN PVHHDVAVLI TRKDICAGVN RPCETLGLSQ LSGMCQPHRS CNINEDSGLP LAFTIAHELG HSFGIQHDGK ENDCEPVGRH PYIMSQQIQY DPTPLTWSKC SKEYITRFLD RGRGFCLDDI P
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
18,843 Da
Sequence Positions
210-460, Partial, include the Cysteine switch motif and Peptidase M12B domain.
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q811B3
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Adamts12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Adamts12 purchase

MBS1329749 is a recombinant protein targeting Adamts12. Also known as Recombinant Mouse A disintegrin and metalloproteinase with thrombospondin motifs 12 (Adamts12) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Adamts12. It may not necessarily be applicable to this product.

NCBI GI #
153945812
NCBI GeneID
239337
NCBI Accession #
NP_780710.2
UniProt Primary Accession #
Q811B3
UniProt Secondary Accession #
Q8BK92; Q8BKY1; E9QKD6
UniProt Related Accession #
Q811B3
GenBank Nucleotide #
NM_175501.3
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
NCBI Official Symbol
Adamts12
NCBI Official Synonym Symbols
AI605170; ADAMTS-12
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 12
Protein Family
A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name
Adamts12
UniProt Synonym Gene Names
ADAM-TS 12; ADAM-TS12; ADAMTS-12
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 12

NCBI Summary for Adamts12

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]
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UniProt Comments for Adamts12

Metalloprotease that plays a role in the degradation of COMP (). Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties ().

Research Articles on Adamts12

1. ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Adamts12 recombinant protein

 Reference Product  PubMed Publications
 Comp recombinant protein  >6 publications with Adamts12 and Comp
 Furin recombinant protein  >2 publications with Adamts12 and Furin
 Grn recombinant protein  >1 publications with Adamts12 and Grn

Diseases associated with Adamts12 recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with Adamts12 and Disease Models, Animal
 Inflammation Antibodies  >4 publications with Adamts12 and Inflammation
 Necrosis Antibodies  >4 publications with Adamts12 and Necrosis
 Mental Disorders Antibodies  >2 publications with Adamts12 and Mental Disorders
 Atherosclerosis Antibodies  >1 publications with Adamts12 and Atherosclerosis
 Arteriosclerosis Antibodies  >1 publications with Adamts12 and Arteriosclerosis
 Brain Diseases Antibodies  >1 publications with Adamts12 and Brain Diseases
 Breast Neoplasms Antibodies  >1 publications with Adamts12 and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with Adamts12 and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with Adamts12 and Kidney Diseases

Organs/Tissues associated with Adamts12 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >5 publications with Adamts12 and Connective Tissue
 Lung Antibodies  >3 publications with Adamts12 and Lung
 Ovary Antibodies  >1 publications with Adamts12 and Ovary
 Embryonic Tissue Antibodies  >1 publications with Adamts12 and Embryonic Tissue
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