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DNA Excision Repair Protein ERCC-8 (ERCC8) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1330013

This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary… More details

$1135 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNA excision repair protein ERCC-8 (Ercc8), Recombinant Protein
Full Product Name
Recombinant Mouse DNA excision repair protein ERCC-8 (Ercc8)
Product Gene Name
Ercc8 recombinant protein
Product Synonym Gene Name
Ercc8
Sequence
MLSFLSARQS GLEDPLRLRR AQSTRRVLGL ELNKDRDVER IHGSGVNTLD IEPVEGRYML SGGSDGVVVL YDLENASRQP HYTCKAVCSV GRSHPDVHKY SVETVQWYPH DTGMFTSSSF DKTLKVWDTN TLQAADVFNF EETVYSHHMS PAATKHCLVA VGTRGPKVQL CDLKSGSCSH ILQGHRQEIL AVSWSPRHDY ILATASADSR VKLWDVRRAS GCLLTLDQHN GKKSQAAESA NTAHNGKVNG LCFTSDGLHL LTIGTDNRMR LWNSSSGDNT LVNYGKVCND SRKGLQFAVS CGCSSEFVFV PHGSTIAVYA VHSGERLAML KGHYKSVDCC VFQPNFQELY SGSRDCNILA WVPPSYEPVP DDDDEAPAKS QLNPAFADAW SSSDEDG
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
43,689 Da
Sequence Positions
1-397, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8CFD5
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Ercc8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ercc8 purchase

MBS1330013 is a recombinant protein targeting Ercc8. Also known as Recombinant Mouse DNA excision repair protein ERCC-8 (Ercc8). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Ercc8. It may not necessarily be applicable to this product.

NCBI GI #
110625789
NCBI GeneID
71991
NCBI Accession #
NP_082318.2
UniProt Primary Accession #
Q8CFD5
UniProt Secondary Accession #
Q3U066; Q8VDC4; Q9CWK7
UniProt Related Accession #
Q8CFD5
GenBank Nucleotide #
NM_028042.3
NCBI Official Full Name
DNA excision repair protein ERCC-8
NCBI Official Synonym Full Names
excision repaiross-complementing rodent repair deficiency, complementation group 8
NCBI Official Symbol
Ercc8
NCBI Official Synonym Symbols
Csa; Ckn1; 2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik
UniProt Protein Name
DNA excision repair protein ERCC-8
UniProt Synonym Protein Names
Cockayne syndrome WD repeat protein CSA homolog
Protein Family
DNA excision repair protein
UniProt Gene Name
Ercc8
UniProt Synonym Gene Names
Ckn1; Csa
NCBI Protein Information
DNA excision repair protein ERCC-8

UniProt Comments for Ercc8

Involved in transcription-coupled nucleotide excision repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. It is the substrate-recognition component of the CSA complex (DCX(ERCC8) complex) which promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.
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Research Articles on Ercc8

1. This study demonistrated that Cockayne syndrome group A deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Ercc8 recombinant protein

 Products by Pathway  Pathway Diagram
 Cul4-DDB1-CSA Complex Pathway antibodies  Cul4-DDB1-CSA Complex Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Dual Incision Reaction In TC-NER Pathway antibodies  Dual Incision Reaction In TC-NER Pathway Diagram
 Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway antibodies  Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Transcription-coupled NER (TC-NER) Pathway antibodies  Transcription-coupled NER (TC-NER) Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with Ercc8 recombinant protein

 Disease Name  Pubmed Publications
 Cockayne Syndrome Antibodies  >52 publications with Ercc8 and Cockayne Syndrome
 Abnormalities, Multiple Antibodies  >35 publications with Ercc8 and Abnormalities, Multiple
 Neoplasms Antibodies  >9 publications with Ercc8 and Neoplasms
 Precancerous Conditions Antibodies  >5 publications with Ercc8 and Precancerous Conditions
 Microcephaly Antibodies  >4 publications with Ercc8 and Microcephaly
 Drug Toxicity Antibodies  >2 publications with Ercc8 and Drug Toxicity
 Brain Diseases Antibodies  >2 publications with Ercc8 and Brain Diseases
 Ovarian Neoplasms Antibodies  >1 publications with Ercc8 and Ovarian Neoplasms
 Prostatic Diseases Antibodies  >1 publications with Ercc8 and Prostatic Diseases
 Disease Models, Animal Antibodies  >1 publications with Ercc8 and Disease Models, Animal

Organs/Tissues associated with Ercc8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >12 publications with Ercc8 and Skin
 Brain Antibodies  >3 publications with Ercc8 and Brain
 Eye Antibodies  >1 publications with Ercc8 and Eye
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