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Transcription Factor E4F1 (E4F1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1330083

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through… More details

$1665 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transcription factor E4F1 (E4f1), Recombinant Protein
Full Product Name
Recombinant Mouse Transcription factor E4F1 (E4f1)
Product Gene Name
E4f1 recombinant protein
Product Synonym Gene Name
E4f1
Sequence
MEGAMAVRVT AAHTAEARAE AGREAGEGGV AAAAALSSGG FLGLPAPFSE EDEDDVHRCG RCQVEFTALE DFVQHKIQKT CHRAPQEALP TTPAATALLD QEVVPTAAEG GPDEPITVAH IVVEATSLAE DISHAPDLVG SGHIKEVIVA AEAEPGDVEM AEAPGSPNHQ ELGLLGEGEQ AHVKLLVNKE GRYVCMLCHK TFKTGSILKA HMVTHSSRKD HECKLCGASF RTKGSLIRHH RRHTDERPYK CAKCGKSFRE SGALTRHLKS LTPCTEKIRF SISKDTAVGK EEVPAGSSAS TVGTVTSSVA GDPMETSPVI HLVTDAKGTV IHEVHVQMQE LPLGMKALTP ESPDSEELPC SSENSRENLL HQAMQNSGIV LERVAGEESA LEPAPPSGSS PQCLGDGSPE LPLLKVEQIE TQVASEAATV PRTHPCPQCS ETFPTAATLE AHKRGHIAPR PFTCTQCGKA FPKAYLLKKH QEVHVHERRF RCGDCGKLYK TIAHVRGHRR VHSDERPFPC PQCGKRYKTK NAQQVHFRTH LEEKPHVCQF CSRGFREKGS LVRHVRHHTG EKPFKCYKCG RGFAEHGTLN RHLRTKGGCL LEVEELLVSE ESPSAAATVL AEDPHTVLVE FSSVVADTQE YIIEATADDT ETSEATEIIE GTQTEVDSHI MKVVQQIVHQ AGAGHQIIVQ NVTMDQETAL GSEATAADTI TIATPESLTE QVAMTLASAI SEGTVLTARA GPNSTEQATV TMVSSEDIEI LEHGGELVIA SPEGQLEVQT VIV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
80,830 Da
Sequence Positions
1-783, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8CCE9
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of E4f1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for E4f1 purchase

MBS1330083 is a recombinant protein targeting E4f1. Also known as Recombinant Mouse Transcription factor E4F1 (E4f1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for E4f1. It may not necessarily be applicable to this product.

NCBI GI #
685156930
NCBI GeneID
13560
NCBI Accession #
NP_001288713.1
UniProt Primary Accession #
Q8CCE9
UniProt Secondary Accession #
Q05BH7; Q3UNJ9; Q62065; Q6IR08; Q6PGI1; Q9QY56
UniProt Related Accession #
Q8CCE9
GenBank Nucleotide #
NM_001301784.1
NCBI Official Full Name
transcription factor E4F1 isoform 1
NCBI Official Synonym Full Names
E4F transcription factor 1
NCBI Official Symbol
E4f1
NCBI Official Synonym Symbols
p120E4F; phi-AP3
UniProt Protein Name
Transcription factor E4F1
UniProt Synonym Protein Names
E4F transcription factor 1; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1Curated; Transcription factor E4F; Transcription factor phi AP3; p120E4F
Protein Family
Transcription factor
UniProt Gene Name
E4f1
NCBI Protein Information
transcription factor E4F1

NCBI Summary for E4f1

This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
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UniProt Comments for E4f1

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.
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Research Articles on E4f1

1. these data identify E4F1 as a master regulator of the PDC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with E4f1 recombinant protein

 Reference Product  PubMed Publications
 Trp53 recombinant protein  >2 publications with E4f1 and Trp53
 Hdac1 recombinant protein  >1 publications with E4f1 and Hdac1
 Cdx4 recombinant protein  >1 publications with E4f1 and Cdx4
 Tcf3 recombinant protein  >1 publications with E4f1 and Tcf3
 Smad4 recombinant protein  >1 publications with E4f1 and Smad4

Diseases associated with E4f1 recombinant protein

 Disease Name  Pubmed Publications
 Death Antibodies  >5 publications with E4f1 and Death
 Cell Transformation, Neoplastic Antibodies  >2 publications with E4f1 and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >1 publications with E4f1 and Carcinoma, Hepatocellular
 Fetal Death Antibodies  >1 publications with E4f1 and Fetal Death
 Liver Diseases Antibodies  >1 publications with E4f1 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with E4f1 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with E4f1 and Liver Neoplasms
 Hyperplasia Antibodies  >1 publications with E4f1 and Hyperplasia

Organs/Tissues associated with E4f1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with E4f1 and Liver
 Ovary Antibodies  >2 publications with E4f1 and Ovary
 Testis Antibodies  >1 publications with E4f1 and Testis
 Lung Antibodies  >1 publications with E4f1 and Lung
 Bone Marrow Antibodies  >1 publications with E4f1 and Bone Marrow
 Kidney Antibodies  >1 publications with E4f1 and Kidney
 Blood Antibodies  >1 publications with E4f1 and Blood
 Mammary Gland Antibodies  >1 publications with E4f1 and Mammary Gland
 Embryonic Tissue Antibodies  >1 publications with E4f1 and Embryonic Tissue
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