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NACHT, LRR and PYD Domains-Containing Protein 10 (NLRP10) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1330087

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein belongs to the NALP protein family despite lacking the LRR… More details

$1470 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NACHT, LRR and PYD domains-containing protein 10 (NLRP10), Recombinant Protein
Full Product Name
Recombinant Human NACHT, LRR and PYD domains-containing protein 10 (NLRP10)
Product Gene Name
NLRP10 recombinant protein
Product Synonym Gene Name
NLRP10
Sequence
MAMAKARKPR EALLWALSDL EENDFKKLKF YLRDMTLSEG QPPLARGELE GLIPVDLAEL LISKYGEKEA VKVVLKGLKV MNLLELVDQL SHICLHDYRE VYREHVRCLE EWQEAGVNGR YNQVLLVAKP SSESPESLAC PFPEQELESV TVEALFDSGE KPSLAPSLVV LQGSAGTGKT TLARKMVLDW ATGTLYPGRF DYVFYVSCKE VVLLLESKLE QLLFWCCGDN QAPVTEILRQ PERLLFILDG FDELQRPFEE KLKKRGLSPK ESLLHLLIRR HTLPTCSLLI TTRPLALRNL EPLLKQARHV HILGFSEEER ARYFSSYFTD EKQADRAFDI VQKNDILYKA CQVPGICWVV CSWLQGQMER GKVVLETPRN STDIFMAYVS TFLPPDDDGG CSELSRHRVL RSLCSLAAEG IQHQRFLFEE AELRKHNLDG PRLAAFLSSN DYQLGLAIKK FYSFRHISFQ DFFHAMSYLV KEDQSRLGKE SRREVQRLLE VKEQEGNDEM TLTMQFLLDI SKKDSFSNLE LKFCFRISPC LAQDLKHFKE QMESMKHNRT WDLEFSLYEA KIKNLVKGIQ MNNVSFKIKH SNEKKSQSQN LFSVKSSLSH GPKEEQKCPS VHGQKEGKDN IAGTQKEAST GKGRGTEETP KNTYI
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
75,032 Da
Sequence Positions
1-655, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
609662
3D Structure
ModBase 3D Structure for Q86W26
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NLRP10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLRP10 purchase

MBS1330087 is a recombinant protein targeting NLRP10. Also known as Recombinant Human NACHT, LRR and PYD domains-containing protein 10 (NLRP10). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRP10. It may not necessarily be applicable to this product.

NCBI GI #
28827807
NCBI GeneID
338322
NCBI Accession #
NP_789791.1
UniProt Primary Accession #
Q86W26
UniProt Secondary Accession #
Q2M3C4; Q6JGT0
UniProt Related Accession #
Q86W26
GenBank Nucleotide #
NM_176821.3
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 10
NCBI Official Synonym Full Names
NLR family pyrin domain containing 10
NCBI Official Symbol
NLRP10
NCBI Official Synonym Symbols
NOD8; PAN5; PYNOD; NALP10; CLR11.1
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 10
UniProt Synonym Protein Names
Nucleotide-binding oligomerization domain protein 8
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP10
UniProt Synonym Gene Names
NALP10; NOD8; PYNOD
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 10

NCBI Summary for NLRP10

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for NLRP10

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819).
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Research Articles on NLRP10

1. Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NLRP10 recombinant protein

 Reference Product  PubMed Publications
 CASP1 recombinant protein  >7 publications with NLRP10 and CASP1
 BECN1 recombinant protein  >1 publications with NLRP10 and BECN1

Pathways associated with NLRP10 recombinant protein

 Products by Pathway  Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram

Diseases associated with NLRP10 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3 publications with NLRP10 and Necrosis
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