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TGF-Beta Receptor Type-2 (TGFBR2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1330265

This gene encodes a member of the SerThr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta.… More details

$1265 / 0.5 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TGF-beta receptor type-2 (Tgfbr2), Recombinant Protein
Full Product Name
Recombinant Mouse TGF-beta receptor type-2 (Tgfbr2), partial
Product Gene Name
Tgfbr2 recombinant protein
Product Synonym Gene Name
Tgfbr2
Sequence
IPPHVPK SDVEMEAQKD ASIHLSCNRT IHPLKHFNSD VMASDNGGAV KLPQLCKFCD VRLSTCDNQK SCMSNCSITA ICEKPHEVCV AVWRKNDKNI TLETVCHDPK LTYHGFTLED AASPKCVMKE KKRAGETFFM CACNMEECND YIIFSEEYTT SSPD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
64,219 Da
Sequence Positions
24-184
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q62312
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tgfbr2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tgfbr2 purchase

MBS1330265 is a recombinant protein targeting Tgfbr2. Also known as Recombinant Mouse TGF-beta receptor type-2 (Tgfbr2), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Tgfbr2. It may not necessarily be applicable to this product.

NCBI GI #
239787881
NCBI GeneID
21813
NCBI Accession #
NP_033397.3
UniProt Primary Accession #
Q62312
UniProt Secondary Accession #
Q63947
UniProt Related Accession #
Q62312
GenBank Nucleotide #
NM_009371.3
NCBI Official Full Name
TGF-beta receptor type-2 isoform 1
NCBI Official Synonym Full Names
transforming growth factor, beta receptor II
NCBI Official Symbol
Tgfbr2
NCBI Official Synonym Symbols
DNIIR; RIIDN; TBR-II; AU042018; TbetaRII; TbetaR-II; 1110020H15Rik
UniProt Protein Name
TGF-beta receptor type-2
UniProt Synonym Protein Names
TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
Protein Family
TGF-beta receptor
UniProt Gene Name
Tgfbr2
UniProt Synonym Gene Names
TGFR-2; TGF-beta receptor type II; TbetaR-II
NCBI Protein Information
TGF-beta receptor type-2

UniProt Comments for Tgfbr2

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways ().
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Research Articles on Tgfbr2

1. miR-130a-3p might play a critical role in negatively regulating hepatic stellate cell activation and proliferation in the progression of nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2 via the TGF-beta/SMAD signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Tgfbr2 recombinant protein

 Reference Product  PubMed Publications
 Tgfbr1 recombinant protein  >165 publications with Tgfbr2 and Tgfbr1
 Tgfb1 recombinant protein  >93 publications with Tgfbr2 and Tgfb1
 Smad3 recombinant protein  >58 publications with Tgfbr2 and Smad3
 Smad2 recombinant protein  >53 publications with Tgfbr2 and Smad2
 Tgfb2 recombinant protein  >43 publications with Tgfbr2 and Tgfb2
 Smad4 recombinant protein  >30 publications with Tgfbr2 and Smad4
 Tgfb3 recombinant protein  >18 publications with Tgfbr2 and Tgfb3
 Smad7 recombinant protein  >14 publications with Tgfbr2 and Smad7
 Smad6 recombinant protein  >6 publications with Tgfbr2 and Smad6

Pathways associated with Tgfbr2 recombinant protein

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 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram

Diseases associated with Tgfbr2 recombinant protein

 Disease Name  Pubmed Publications
 Aortic Aneurysm Antibodies  >108 publications with Tgfbr2 and Aortic Aneurysm
 Marfan Syndrome Antibodies  >92 publications with Tgfbr2 and Marfan Syndrome
 Carcinoma Antibodies  >87 publications with Tgfbr2 and Carcinoma
 Loeys-Dietz Syndrome Antibodies  >86 publications with Tgfbr2 and Loeys-Dietz Syndrome
 Heart Diseases Antibodies  >82 publications with Tgfbr2 and Heart Diseases
 Bone Diseases Antibodies  >78 publications with Tgfbr2 and Bone Diseases
 Craniofacial Abnormalities Antibodies  >67 publications with Tgfbr2 and Craniofacial Abnormalities
 Aneurysm, Dissecting Antibodies  >62 publications with Tgfbr2 and Aneurysm, Dissecting
 Aortic Aneurysm, Thoracic Antibodies  >56 publications with Tgfbr2 and Aortic Aneurysm, Thoracic
 Microsatellite Instability Antibodies  >52 publications with Tgfbr2 and Microsatellite Instability

Organs/Tissues associated with Tgfbr2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >73 publications with Tgfbr2 and Connective Tissue
 Bone Antibodies  >72 publications with Tgfbr2 and Bone
 Muscle Antibodies  >63 publications with Tgfbr2 and Muscle
 Heart Antibodies  >49 publications with Tgfbr2 and Heart
 Embryonic Tissue Antibodies  >40 publications with Tgfbr2 and Embryonic Tissue
 Lung Antibodies  >39 publications with Tgfbr2 and Lung
 Liver Antibodies  >33 publications with Tgfbr2 and Liver
 Joint Antibodies  >28 publications with Tgfbr2 and Joint
 Brain Antibodies  >27 publications with Tgfbr2 and Brain
 Prostate Antibodies  >20 publications with Tgfbr2 and Prostate
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