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Methylcytosine Dioxygenase TET2 (TET2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1330723

MBS1330723 is a recombinant protein targeting Tet2. Also known as Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Methylcytosine dioxygenase TET2 (Tet2), Recombinant Protein
Full Product Name
Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2) , partial
Product Gene Name
Tet2 recombinant protein
Product Synonym Gene Name
Tet2
Sequence
RISLVLYRHK NLFLPKHCLA LWEAKMAEKA RKEEECGKNG SDHVSQKNHG KQEKREPTGP QEPSYLRFIQ SLAENTGSVT TDSTVTTSPY AFTQVTGPYN TFV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
27.0 kDa
Sequence Positions
1810-1912. Fragment at the C-terminal.
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q4JK59
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tet2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tet2. It may not necessarily be applicable to this product.

NCBI GI #
157057152
NCBI GeneID
214133
NCBI Accession #
NP_001035490.2
UniProt Primary Accession #
Q4JK59
UniProt Secondary Accession #
Q3U5R5; Q3U633; Q3UAI0; Q6ZPN2; Q8K2K3
UniProt Related Accession #
Q4JK59
GenBank Nucleotide #
NM_001040400.2
NCBI Official Full Name
methylcytosine dioxygenase TET2 isoform 1
NCBI Official Synonym Full Names
tet methylcytosine dioxygenase 2
NCBI Official Symbol
Tet2
NCBI Official Synonym Symbols
Ayu17-449; mKIAA1546; E130014J05Rik
UniProt Protein Name
Methylcytosine dioxygenase TET2
UniProt Synonym Protein Names
Protein Ayu17-449
Protein Family
Methylcytosine dioxygenase
UniProt Gene Name
Tet2
UniProt Synonym Gene Names
Kiaa1546
NCBI Protein Information
methylcytosine dioxygenase TET2

UniProt Comments for Tet2

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
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Research Articles on Tet2

1. we identified that TET2 was downregulated during the pathogenesis of atherosclerosis. The downregulation of TET2 promotes the methylation of the Beclin 1 promoter, leading to endothelial cell autophagy, impaired autophagic flux, and inflammatory factor upregulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Tet2 recombinant protein

 Reference Product  PubMed Publications
 Sin3a recombinant protein  >2 publications with Tet2 and Sin3a
 Hdac1 recombinant protein  >1 publications with Tet2 and Hdac1
 Apobec1 recombinant protein  >1 publications with Tet2 and Apobec1

Pathways associated with Tet2 recombinant protein

 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TET1,2,3 And TDG Demethylate DNA Pathway antibodies  TET1,2,3 And TDG Demethylate DNA Pathway Diagram

Diseases associated with Tet2 recombinant protein

 Disease Name  Pubmed Publications
 Myelodysplastic Syndromes Antibodies  >141 publications with Tet2 and Myelodysplastic Syndromes
 Carcinoma Antibodies  >19 publications with Tet2 and Carcinoma
 Lymphoma, T-Cell, Peripheral Antibodies  >17 publications with Tet2 and Lymphoma, T-Cell, Peripheral
 Cardiovascular Diseases Antibodies  >15 publications with Tet2 and Cardiovascular Diseases
 Skin Diseases Antibodies  >13 publications with Tet2 and Skin Diseases
 Breast Neoplasms Antibodies  >9 publications with Tet2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >8 publications with Tet2 and Neoplasms, Experimental
 Abnormalities, Multiple Antibodies  >8 publications with Tet2 and Abnormalities, Multiple
 Fibrosis Antibodies  >7 publications with Tet2 and Fibrosis
 Inflammation Antibodies  >7 publications with Tet2 and Inflammation

Organs/Tissues associated with Tet2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >161 publications with Tet2 and Blood
 Bone Marrow Antibodies  >88 publications with Tet2 and Bone Marrow
 Brain Antibodies  >32 publications with Tet2 and Brain
 Embryonic Tissue Antibodies  >17 publications with Tet2 and Embryonic Tissue
 Skin Antibodies  >12 publications with Tet2 and Skin
 Heart Antibodies  >10 publications with Tet2 and Heart
 Lung Antibodies  >8 publications with Tet2 and Lung
 Kidney Antibodies  >6 publications with Tet2 and Kidney
 Spleen Antibodies  >5 publications with Tet2 and Spleen
 Testis Antibodies  >4 publications with Tet2 and Testis
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