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Bis (5'-Adenosyl)-Triphosphatase (FHIT) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1331063

MBS1331063 is a recombinant protein targeting Fhit. Also known as Recombinant Rat Bis (5'-adenosyl)-triphosphatase (Fhit). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$800 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Bis (5'-adenosyl)-triphosphatase (Fhit), Recombinant Protein
Full Product Name
Recombinant Rat Bis (5'-adenosyl)-triphosphatase (Fhit)
Product Gene Name
Fhit recombinant protein
Product Synonym Gene Name
Fhit
Sequence
MSFKFGQHLI KPSVVFLKTE LSFALVNRKP VVPGHVLMCP LRPVERFRDL RPDEVADLFQ VTQRVGTVVE KHFQGTSITF SMQDGPEAGQ TVKHVHVHIL PRKSGDFRRN DNIYDELQKH DREEEDSPAF WRSEEEMAAE AEVLRAYFQA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
17,348 Da
Sequence Positions
1-150, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9JIX3
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Fhit recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Fhit. It may not necessarily be applicable to this product.

NCBI GI #
11120730
NCBI GeneID
60398
NCBI Accession #
NP_068542.1
UniProt Primary Accession #
Q9JIX3
UniProt Related Accession #
Q9JIX3
GenBank Nucleotide #
NM_021774.1
NCBI Official Full Name
bis(5'-adenosyl)-triphosphatase
NCBI Official Synonym Full Names
fragile histidine triad
NCBI Official Symbol
Fhit
UniProt Protein Name
Bis(5'-adenosyl)-triphosphatase
UniProt Synonym Protein Names
AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein
Protein Family
Bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase
UniProt Gene Name
Fhit
UniProt Synonym Gene Names
AP3Aase
NCBI Protein Information
bis(5'-adenosyl)-triphosphatase

NCBI Summary for Fhit

may play a role in the development of hepatocellular carcinomas (HCCs) induced by N-nitrosodiethylamine (DEN) [RGD, Feb 2006]

UniProt Comments for Fhit

Cleaves P1-P3-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P1-P4-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity. Functions as tumor suppressor ().
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Research Articles on Fhit

1. Nickel(II) treatment down-regulated Fhit expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Fhit recombinant protein

 Reference Product  PubMed Publications
 Hint1 recombinant protein  >9 publications with Fhit and Hint1
 Src recombinant protein  >9 publications with Fhit and Src
 Fdxr recombinant protein  >4 publications with Fhit and Fdxr

Pathways associated with Fhit recombinant protein

 Products by Pathway  Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Small Cell Lung Cancer Pathway antibodies  Small Cell Lung Cancer Pathway Diagram
 Small Cell Lung Cancer Pathway antibodies  Small Cell Lung Cancer Pathway Diagram

Diseases associated with Fhit recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >524 publications with Fhit and Carcinoma
 Lung Neoplasms Antibodies  >185 publications with Fhit and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >172 publications with Fhit and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >155 publications with Fhit and Lung Diseases
 Breast Neoplasms Antibodies  >94 publications with Fhit and Breast Neoplasms
 Carcinoma, Non-Small-Cell Lung Antibodies  >93 publications with Fhit and Carcinoma, Non-Small-Cell Lung
 Neoplasm Metastasis Antibodies  >88 publications with Fhit and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >85 publications with Fhit and Neoplasms, Experimental
 Stomach Neoplasms Antibodies  >69 publications with Fhit and Stomach Neoplasms
 Uterine Cervical Neoplasms Antibodies  >64 publications with Fhit and Uterine Cervical Neoplasms

Organs/Tissues associated with Fhit recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with Fhit and Brain
 Heart Antibodies  >5 publications with Fhit and Heart
 Eye Antibodies  >2 publications with Fhit and Eye
 Ovary Antibodies  >2 publications with Fhit and Ovary
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