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Protein SMG7 (SMG7) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1331405

MBS1331405 is a recombinant protein targeting SMG7. Also known as Recombinant Human Protein SMG7 (SMG7) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1295 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Protein SMG7 (SMG7), Recombinant Protein
Full Product Name
Recombinant Human Protein SMG7 (SMG7) , partial
Product Gene Name
SMG7 recombinant protein
Product Synonym Gene Name
SMG7
Sequence
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
127,854 Da
Sequence Positions
1-497. Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
610964
3D Structure
ModBase 3D Structure for Q92540
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SMG7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SMG7. It may not necessarily be applicable to this product.

NCBI GI #
291327485
NCBI GeneID
9887
NCBI Accession #
NP_001167532.1
UniProt Primary Accession #
Q92540
UniProt Secondary Accession #
Q5T1Q0; Q6PIE0; Q7Z7H9; Q8IXC1; Q8IXC2; B4DRB2; E9PCI0; E9PEH2
UniProt Related Accession #
Q92540
GenBank Nucleotide #
NM_001174061.1
NCBI Official Full Name
protein SMG7 isoform 5
NCBI Official Synonym Full Names
SMG7, nonsense mediated mRNA decay factor
NCBI Official Symbol
SMG7
NCBI Official Synonym Symbols
EST1C; SGA56M; C1orf16
UniProt Protein Name
Protein SMG7
UniProt Synonym Protein Names
EST1-like protein C; SMG-7 homolog; hSMG-7
Protein Family
Protein
UniProt Gene Name
SMG7
UniProt Synonym Gene Names
C1orf16; EST1C; KIAA0250; hSMG-7
NCBI Protein Information
protein SMG7

NCBI Summary for SMG7

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
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UniProt Comments for SMG7

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
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Research Articles on SMG7

1. Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SMG7 recombinant protein

 Reference Product  PubMed Publications
 UPF1 recombinant protein  >15 publications with SMG7 and UPF1
 SMG5 recombinant protein  >15 publications with SMG7 and SMG5

Pathways associated with SMG7 recombinant protein

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Nonsense Mediated Decay Enhanced By The Exon Junction Complex Pathway antibodies  Nonsense Mediated Decay Enhanced By The Exon Junction Complex Pathway Diagram
 Nonsense-Mediated Decay Pathway antibodies  Nonsense-Mediated Decay Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram

Diseases associated with SMG7 recombinant protein

 Disease Name  Pubmed Publications
 Death Antibodies  >1 publications with SMG7 and Death

Organs/Tissues associated with SMG7 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with SMG7 and Blood
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