Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 (CREB3L2) Human Recombinant Protein

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Membrane protein, integral; Oncoprotein

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus

Biological Process: ER to Golgi vesicle-mediated transport; transcription, DNA-dependent; unfolded protein response; positive regulation of transcription, DNA-dependent; cartilage development; chondrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter