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Neurochondrin (NCDN) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1331824

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Cacalmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively… More details

$1585 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neurochondrin (NCDN), Recombinant Protein
Full Product Name
Recombinant Human Neurochondrin (NCDN)
Product Gene Name
NCDN recombinant protein
Product Synonym Gene Name
NCDN
Sequence
SCCDLAAAGQ LGKASIMASD CEPALNQAEG RNPTLERYLG ALREAKNDSE QFAALLLVTK AVKAGDIDAK TRRRIFDAVG FTFPNRLLTT KEAPDGCPDH VLRALGVALL ACFCSDPELA AHPQVLNKIP ILSTFLTARG DPDDAARRSM IDDTYQCLTA VAGTPRGPRH LIAGGTVSAL CQAYLGHGYG FDQALALLVG LLAAAETQCW KEAEPDLLAV LRGLSEDFQK AEDASKFELC QLLPLFLPPT TVPPECYRDL QAGLARILGS KLSSWQRNPA LKLAARLAHA CGSDWIPAGS SGSKFLALLV NLACVEVRLA LEETGTEVKE DVVTACYALM ELGIQECTRC EQSLLKEPQK VQLVSVMKEA IGAVIHYLLQ VGSEKQKEPF VFASVRILGA WLAEETSSLR KEVCQLLPFL VRYAKTLYEE AEEANDLSQQ VANLAISPTT PGPTWPGDAL RLLLPGWCHL TVEDGPREIL IKEGAPSLLC KYFLQQWELT SPGHDTSVLP DSVEIGLQTC CHIFLNLVVT APGLIKRDAC FTSLMNTLMT SLPALVQQQG RLLLAANVAT LGLLMARLLS TSPALQGTPA SRGFFAAAIL FLSQSHVARA TPGSDQAVLA LSPEYEGIWA DLQELWFLGM QAFTGCVPLL PWLAPAALRS RWPQELLQLL GSVSPNSVKP EMVAAYQGVL VELARANRLC REAMRLQAGE ETASHYRMAA LEQCLSEP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
79,158 Da
Sequence Positions
2-729, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
608458
3D Structure
ModBase 3D Structure for Q9UBB6
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NCDN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCDN purchase

MBS1331824 is a recombinant protein targeting NCDN. Also known as Recombinant Human Neurochondrin (NCDN). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NCDN. It may not necessarily be applicable to this product.

NCBI GI #
62526029
NCBI GeneID
23154
NCBI Accession #
NP_001014839.1
UniProt Primary Accession #
Q9UBB6
UniProt Secondary Accession #
Q9UBY2; Q9Y4A6; Q9Y4D9; D3DPR9
UniProt Related Accession #
Q9UBB6
GenBank Nucleotide #
NM_001014839.1
NCBI Official Full Name
neurochondrin isoform 1
NCBI Official Synonym Full Names
neurochondrin
NCBI Official Symbol
NCDN
UniProt Protein Name
Neurochondrin
Protein Family
Neurochondrin
UniProt Gene Name
NCDN
UniProt Synonym Gene Names
KIAA0607
NCBI Protein Information
neurochondrin

NCBI Summary for NCDN

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for NCDN

Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (). Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
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Research Articles on NCDN

1. Schizophrenia subjects compared to controls showed a marked increase in CA1 hippocampal Norbin, and Tamalin proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 signalling and trafficking

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with NCDN recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with NCDN and Brain
 Nerve Antibodies  >1 publications with NCDN and Nerve
 Blood Antibodies  >1 publications with NCDN and Blood
 Embryonic Tissue Antibodies  >1 publications with NCDN and Embryonic Tissue
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