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Probable 8-Oxo-Dgtp Diphosphatase NUDT15 (NUDT15) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1333052

MBS1333052 is a recombinant protein targeting Nudt15. Also known as Recombinant Mouse Probable 8-oxo-dGTP diphosphatase NUDT15 (Nudt15). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$825 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Probable 8-oxo-dGTP diphosphatase NUDT15 (Nudt15), Recombinant Protein
Full Product Name
Recombinant Mouse Probable 8-oxo-dGTP diphosphatase NUDT15 (Nudt15)
Product Gene Name
Nudt15 recombinant protein
Product Synonym Gene Name
Nudt15
Sequence
MAANAEPRRR PGVGVGVVVL SCEHPRCVLL GKRKGSFGAG SFQLPGGHLE FGETWEECAQ RETWEEAGLH LKNVCFASVV NSFVEKENYH YVTILMKGEV DMTHDSEPRN MEPEKNESWE WVPWEEFPPL DQLFWALRCL KEQGYDPFKE DLNHLEGYRG EHLERTTKTP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
19,576 Da
Sequence Positions
1-170, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8BG93
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nudt15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Nudt15. It may not necessarily be applicable to this product.

NCBI GI #
27369730
NCBI GeneID
214254
NCBI Accession #
NP_766115.1
UniProt Primary Accession #
Q8BG93
UniProt Related Accession #
Q8BG93
GenBank Nucleotide #
NM_172527.3
NCBI Official Full Name
nucleotide triphosphate diphosphatase NUDT15
NCBI Official Synonym Full Names
nudix (nucleoside diphosphate linked moiety X)-type motif 15
NCBI Official Symbol
Nudt15
NCBI Official Synonym Symbols
MTH2; 6530403O17; A730068G11Rik
UniProt Protein Name
Nucleotide triphosphate diphosphatase NUDT15
UniProt Synonym Protein Names
MutT homolog 2
Protein Family
Nucleotide triphosphate diphosphatase
UniProt Gene Name
Nudt15
UniProt Synonym Gene Names
Nudix hydrolase 15
NCBI Protein Information
nucleotide triphosphate diphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15

UniProt Comments for Nudt15

May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:12767940). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:12767940). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA ().
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Research Articles on Nudt15

1. These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Nudt15 recombinant protein

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Phosphate Bond Hydrolysis By NUDT Proteins Pathway antibodies  Phosphate Bond Hydrolysis By NUDT Proteins Pathway Diagram

Diseases associated with Nudt15 recombinant protein

 Disease Name  Pubmed Publications
 Leukopenia Antibodies  >1 publications with Nudt15 and Leukopenia

Organs/Tissues associated with Nudt15 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with Nudt15 and Eye
 Other Antibodies  >1 publications with Nudt15 and Other
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