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G-Protein-Signaling Modulator 1 (GPSM1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1333899

MBS1333899 is a recombinant protein targeting GPSM1. Also known as Recombinant Human G-protein-signaling modulator 1 (GPSM1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1510 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
G-protein-signaling modulator 1 (GPSM1), Recombinant Protein
Full Product Name
Recombinant Human G-protein-signaling modulator 1 (GPSM1)
Product Gene Name
GPSM1 recombinant protein
Product Synonym Gene Name
GPSM1
Sequence
MAGPAPPVAD ELPGPAARRL YSRMEASCLE LALEGERLCK AGDFKTGVAF FEAAVQVGTE DLKTLSAIYS QLGNAYFYLK EHGRALEYHK HDLLLARTIG DRMGEAKASG NLGNTLKVLG RFDEAAVCCQ RHLSIAQEQG DKVGEARALY NIGNVYHAKG KQLSWNAANA TQDPGHLPPD VRETLCKASE FYERNLSLVK ELGDRAAQGR AYGNLGNTHY LLGNFTEATT FHKERLAIAK EFGDKAAERR AYSNLGNAHV FLGRFDVAAE YYKKTLQLSR QLRDQAVEAQ ACYSLGNTYT LLQDYERAAE YHLRHLLIAQ ELADRVGEGR ACWSLGNAYV SMGRPAQALT FAKKHLQISQ EIGDRHGELT ARMNVAQLQL VLGRLTSPAA SEKPDLAGYE AQGARPKRTQ RLSAETWDLL RLPLEREQNG DSHHSGDWRG PSRDSLPLPV RSRKYQEGPD AERRPREGSH SPLDSADVRV HVPRTSIPRA PSSDEECFFD LLTKFQSSRM DDQRCPLDDG QAGAAEATAA PTLEDRIAQP SMTASPQTEE FFDLIASSQS RRLDDQRASV GSLPGLRITH SNAGHLRGHG EPQEPGDDFF NMLIKYQSSR IDDQRCPPPD VLPRGPTMPD EDFFSLIQRV QAKRMDEQRV DLAGGPEQGA GGPPEPQQQC QPGAS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
72,136 Da
Sequence Positions
1-675, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
609491
3D Structure
ModBase 3D Structure for Q86YR5
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GPSM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GPSM1. It may not necessarily be applicable to this product.

NCBI GI #
525313748
NCBI GeneID
26086
NCBI Accession #
NP_001139110.2
UniProt Primary Accession #
Q86YR5
UniProt Secondary Accession #
Q86SR5; Q969T1; Q9UFS8; A9Z1X4; B1B0W3
UniProt Related Accession #
Q86YR5
GenBank Nucleotide #
NM_001145638.2
NCBI Official Full Name
G-protein-signaling modulator 1 isoform a
NCBI Official Synonym Full Names
G protein signaling modulator 1
NCBI Official Symbol
GPSM1
NCBI Official Synonym Symbols
AGS3
UniProt Protein Name
G-protein-signaling modulator 1
UniProt Synonym Protein Names
Activator of G-protein signaling 3
Protein Family
G-protein-signaling modulator
UniProt Gene Name
GPSM1
UniProt Synonym Gene Names
AGS3
NCBI Protein Information
G-protein-signaling modulator 1

NCBI Summary for GPSM1

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for GPSM1

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
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Research Articles on GPSM1

1. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and AGS3 in fine-tuning TRPC4 activities.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GPSM1 recombinant protein

 Reference Product  PubMed Publications
 USP9X recombinant protein  >1 publications with GPSM1 and USP9X
 KLF5 recombinant protein  >1 publications with GPSM1 and KLF5
 STK11 recombinant protein  >1 publications with GPSM1 and STK11
 FRMPD1 recombinant protein  >1 publications with GPSM1 and FRMPD1
 INSC recombinant protein  >1 publications with GPSM1 and INSC

Pathways associated with GPSM1 recombinant protein

 Products by Pathway  Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram

Diseases associated with GPSM1 recombinant protein

 Disease Name  Pubmed Publications
 Cocaine-Related Disorders Antibodies  >4 publications with GPSM1 and Cocaine-Related Disorders
 Substance Withdrawal Syndrome Antibodies  >3 publications with GPSM1 and Substance Withdrawal Syndrome
 Renal Insufficiency Antibodies  >1 publications with GPSM1 and Renal Insufficiency
 Cardiovascular Diseases Antibodies  >1 publications with GPSM1 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >1 publications with GPSM1 and Drug Toxicity

Organs/Tissues associated with GPSM1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with GPSM1 and Brain
 Eye Antibodies  >3 publications with GPSM1 and Eye
 Kidney Antibodies  >2 publications with GPSM1 and Kidney
 Muscle Antibodies  >2 publications with GPSM1 and Muscle
 Connective Tissue Antibodies  >1 publications with GPSM1 and Connective Tissue
 Heart Antibodies  >1 publications with GPSM1 and Heart
 Nerve Antibodies  >1 publications with GPSM1 and Nerve
 Ovary Antibodies  >1 publications with GPSM1 and Ovary
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