Mouse POT1 Recombinant Protein – Cat# MBS1334074

Protection of Telomeres Protein 1 (POT1) Mouse Recombinant Protein

Name: POT1 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1334074
Price: 1455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1334074

This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length… More details

$1455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Protection of telomeres protein 1 (Pot1), Recombinant Protein

Full Product Name

Recombinant Mouse Protection of telomeres protein 1 (Pot1)

Product Gene Name

Pot1 recombinant protein

Product Synonym Gene Name

Pot1

Sequence

MSLVSTAPYT YTPLNLLKEG TIANVYGVVK FFKPPYVSKG TDYCSVVTIV DQTNVKLTCM LFSGNYEALP IIYKVGDIVR FHRLKIQVYK NELQGINCSG FASLTFEGTV GMPVTARTSS KVFSFTPQDQ KMVEALRVWA SKHISASSTL VQLCDAQPMQ YYDLTCQLLG KAQVDSTAFL LKVWDGTQTV LPSWRVSTQD LTFEGDLSHI ERLQSLVVDI LVYDNHVQVA RSIEVGCFLR LYSLHTKLQP GNSETSSSES LRLEFHLHGG TSYGRGIRVL PDTSPCVDQL KKALEGANLP VTETSTGICQ SENGDSSALS NSGSGAVSPY EEERCQQVSA TILTNHQHLE KTPLCAILTQ KAPQQYRVRA KLRSYLPRRL SQSVKLLCPK CHSVQEVPHG DSLDKILQDA ATEAPDIKLK ATSLYYSKVW TTEDQGGRQV AVHFVKNNGI LPASSECLIL IEGGRLCEVS KLSSKFHSVM PVRSGPESLE LLTLSAPFLI QGKVHHYGCK QCSSLKPIQN LNSRFHKGPW TPSSVAEALG VVPLQYVFVM VFTLDDGTGV LEAYLKDSEH FFKIPASEVL TDDDLQRSLE TIMDMICPPG IKVDAYPWLE CLLKSYNVTI GTERRICYQI FDTTVAENVV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

59,299 Da

Sequence Positions

1-640, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q91WC1

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Pot1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pot1 purchase

MBS1334074 is a recombinant protein targeting Pot1. Also known as Recombinant Mouse Protection of telomeres protein 1 (Pot1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Pot1. It may not necessarily be applicable to this product.

NCBI GI #

19527150

NCBI GeneID

101185

NCBI Accession #

NP_598692.1

UniProt Primary Accession #

Q91WC1

UniProt Secondary Accession #

Q8BUH9

UniProt Related Accession #

Q91WC1

GenBank Nucleotide #

NM_133931.4

NCBI Official Full Name

protection of telomeres protein 1

NCBI Official Synonym Full Names

protection of telomeres 1A

NCBI Official Symbol

Pot1a

NCBI Official Synonym Symbols

Pot1; AI851169; 1500031H18Rik

UniProt Protein Name

Protection of telomeres protein 1

UniProt Synonym Protein Names

POT1-like telomere end-binding protein

Protein Family

3-ketoacyl-CoA thiolase

UniProt Gene Name

Pot1

UniProt Synonym Gene Names

Pot1a; mPot1

NCBI Protein Information

protection of telomeres protein 1

UniProt Comments for Pot1

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity ().

Research Articles on Pot1

1. The telomere binding protein POT1a inhibits the production of reactive oxygen species, and rejuvenates aged hematopoietic stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Pot1 recombinant protein

Reference Product	PubMed Publications
TERF1 recombinant protein	>10 publications with Pot1 and TERF1
TNKS recombinant protein	>9 publications with Pot1 and TNKS
ACD recombinant protein	>6 publications with Pot1 and ACD

Pathways associated with Pot1 recombinant protein

Products by Pathway	Pathway Diagram
Chromosome Maintenance Pathway antibodies	Chromosome Maintenance Pathway Diagram
Packaging Of Telomere Ends Pathway antibodies	Packaging Of Telomere Ends Pathway Diagram
Regulation Of Telomerase Pathway antibodies	Regulation Of Telomerase Pathway Diagram
Telomere Maintenance Pathway antibodies	Telomere Maintenance Pathway Diagram

Diseases associated with Pot1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>30 publications with Pot1 and Neoplasms
Breast Neoplasms Antibodies	>5 publications with Pot1 and Breast Neoplasms
Lung Neoplasms Antibodies	>4 publications with Pot1 and Lung Neoplasms
Stomach Neoplasms Antibodies	>3 publications with Pot1 and Stomach Neoplasms
Carcinoma, Squamous Cell Antibodies	>3 publications with Pot1 and Carcinoma, Squamous Cell
Neoplasm Metastasis Antibodies	>2 publications with Pot1 and Neoplasm Metastasis
Adenocarcinoma Antibodies	>2 publications with Pot1 and Adenocarcinoma
Melanoma Antibodies	>2 publications with Pot1 and Melanoma
Inflammation Antibodies	>1 publications with Pot1 and Inflammation
Neoplasm Recurrence, Local Antibodies	>1 publications with Pot1 and Neoplasm Recurrence, Local

Organs/Tissues associated with Pot1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with Pot1 and Blood
Bone Antibodies	>6 publications with Pot1 and Bone
Lung Antibodies	>4 publications with Pot1 and Lung
Bone Marrow Antibodies	>4 publications with Pot1 and Bone Marrow
Stomach Antibodies	>3 publications with Pot1 and Stomach
Kidney Antibodies	>2 publications with Pot1 and Kidney
Intestine Antibodies	>2 publications with Pot1 and Intestine
Skin Antibodies	>2 publications with Pot1 and Skin
Brain Antibodies	>2 publications with Pot1 and Brain
Muscle Antibodies	>1 publications with Pot1 and Muscle