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Platelet Endothelial Cell Adhesion Molecule (PECAM1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1334805

MBS1334805 is a recombinant protein targeting Pecam1. Also known as Recombinant Rat Platelet endothelial cell adhesion molecule (Pecam1), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1860 / 0.5 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Platelet endothelial cell adhesion molecule (Pecam1), Recombinant Protein
Full Product Name
Recombinant Rat Platelet endothelial cell adhesion molecule (Pecam1), partial
Product Gene Name
Pecam1 recombinant protein
Product Synonym Gene Name
Pecam1
Sequence
QEN SFTINSIHME SRPSWEVSNG QKLTLQCLVD ISTTSKSRPQ HQVLFYKDDA LVYNVSSSEH TESFVIPQSR VFHAGKYKCT VILNSKEKTT IEYQLTVNGV PMPEVTVDKK EVTEGGIVTV NCSMQEEKPP IYFKIEKVEL GTKNVKLSRE KTSNMNFVLI EFPIEEQDHL LVFRCQAGVL SGIKMQTSEF IRSEYVTVQE FFSTPKFQIQ PPEMIIEGNQ LHIKCSVQVA HLAQEFPEII IQKDKAIVAT SKQSKEAVYS VMALVEHSGH YTCKVESNRI SKASSILVNI TELFPRPKLE LSSSRLDQGE MLDLSCSVSG APVANFTIQK EETVLSQYQN FSKIAEERDS GLYSCTAGIG KVVKRSNLVP VQVCEMLSKP RIFHDAKFEI IKGQIIGISC QSVNGTAPIT YRLLRAKSNF QTVQKNSNDP VTFTDKPTRD MEYQCIVDNC HSHPEVRSEI LRVKVIAPVD EVTISILSGN DVQSGDEMVL RCSVKEGTGP VTFQFYKEKE GRPFHEETVN DTQVFWHHEQ TSKEQEGQYY CTAFNRASIV TSLRSGPLTV RVFLAPWKK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
76,189 Da
Sequence Positions
18-589
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q3SWT0
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Pecam1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Pecam1. It may not necessarily be applicable to this product.

NCBI GI #
75832033
NCBI GeneID
29583
NCBI Accession #
NP_113779.1
UniProt Primary Accession #
Q3SWT0
UniProt Secondary Accession #
P97635
UniProt Related Accession #
Q3SWT0
GenBank Nucleotide #
NM_031591.1
NCBI Official Full Name
platelet endothelial cell adhesion molecule
NCBI Official Synonym Full Names
platelet and endothelial cell adhesion molecule 1
NCBI Official Symbol
Pecam1
NCBI Official Synonym Symbols
CD31; Pecam
UniProt Protein Name
Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names
CD_antigen: CD31
Protein Family
Platelet endothelial cell adhesion molecule
UniProt Gene Name
Pecam1
UniProt Synonym Gene Names
Pecam; PECAM-1
NCBI Protein Information
platelet endothelial cell adhesion molecule

NCBI Summary for Pecam1

cell adhesion molecule, also intracellular signaling molecule; may mediate leukocyte adhesion and migration, angiogenesis, and thrombosis [RGD, Feb 2006]

UniProt Comments for Pecam1

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis.
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Research Articles on Pecam1

1. Circulating PECAM-1 is a promising biomarker for the detection and monitoring of ventilator-induced lung injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Pecam1 recombinant protein

 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with Pecam1 and FLNA

Pathways associated with Pecam1 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram

Diseases associated with Pecam1 recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >635 publications with Pecam1 and Cardiovascular Diseases
 Inflammation Antibodies  >511 publications with Pecam1 and Inflammation
 Necrosis Antibodies  >406 publications with Pecam1 and Necrosis
 Neoplasms, Experimental Antibodies  >264 publications with Pecam1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >247 publications with Pecam1 and Lung Diseases
 Heart Diseases Antibodies  >235 publications with Pecam1 and Heart Diseases
 Breast Neoplasms Antibodies  >209 publications with Pecam1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >193 publications with Pecam1 and Lung Neoplasms
 Liver Diseases Antibodies  >181 publications with Pecam1 and Liver Diseases
 Liver Neoplasms Antibodies  >157 publications with Pecam1 and Liver Neoplasms

Organs/Tissues associated with Pecam1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >512 publications with Pecam1 and Embryonic Tissue
 Artery Antibodies  >483 publications with Pecam1 and Artery
 Lung Antibodies  >443 publications with Pecam1 and Lung
 Heart Antibodies  >359 publications with Pecam1 and Heart
 Brain Antibodies  >325 publications with Pecam1 and Brain
 Eye Antibodies  >184 publications with Pecam1 and Eye
 Placenta Antibodies  >109 publications with Pecam1 and Placenta
 Spleen Antibodies  >101 publications with Pecam1 and Spleen
 Prostate Antibodies  >88 publications with Pecam1 and Prostate
 Pancreas Antibodies  >62 publications with Pecam1 and Pancreas
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