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MOB Kinase Activator 1b (MOB1B) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1335219

This protein is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. More details

$870 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MOB kinase activator 1B (Mob1b), Recombinant Protein
Full Product Name
Recombinant Mouse MOB kinase activator 1B (Mob1b)
Product Gene Name
Mob1b recombinant protein
Product Synonym Gene Name
Mob1b
Sequence
SFLFGSRSSK TFKPKKNIPE GSHQYELLKH AEATLGSGNL RMAVMLPEGE DLNEWVAVNT VDFFNQINML YGTITDFCTE ESCPVMSAGP KYEYHWADGT NIKKPIKCSA PKYIDYLMTW VQDQLDDETL FPSKIGVPFP KNFMSVAKTI LKRLFRVYAH IYHQHFDPVI QLQEEAHLNT SFKHFIFFVQ EFNLIDRREL APLQELIEKL TSKDR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
25,091 Da
Sequence Positions
2-216, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8BPB0
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Mob1b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mob1b purchase

MBS1335219 is a recombinant protein targeting Mob1b. Also known as Recombinant Mouse MOB kinase activator 1B (Mob1b). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Mob1b. It may not necessarily be applicable to this product.

NCBI GI #
62412947
NCBI GeneID
68473
NCBI Accession #
NP_081011.1
UniProt Primary Accession #
Q8BPB0
UniProt Related Accession #
Q8BPB0
GenBank Nucleotide #
NM_026735.2
NCBI Official Full Name
MOB kinase activator 1B
NCBI Official Synonym Full Names
MOB kinase activator 1B
NCBI Official Symbol
Mob1b
NCBI Official Synonym Symbols
Mobkl1a; AU015450; B230364F10; 1110003E08Rik
UniProt Protein Name
MOB kinase activator 1B
UniProt Synonym Protein Names
Mob1 homolog 1A; Mps one binder kinase activator-like 1A
Protein Family
MOB kinase activator
UniProt Gene Name
Mob1b
UniProt Synonym Gene Names
Mobkl1a
NCBI Protein Information
MOB kinase activator 1B

UniProt Comments for Mob1b

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L ().
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Research Articles on Mob1b

1. MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Mob1b recombinant protein

 Reference Product  PubMed Publications
 Lats1 recombinant protein  >10 publications with Mob1b and Lats1
 Lats2 recombinant protein  >6 publications with Mob1b and Lats2
 Stk4 recombinant protein  >4 publications with Mob1b and Stk4
 Stk3 recombinant protein  >4 publications with Mob1b and Stk3
 Stk38l recombinant protein  >3 publications with Mob1b and Stk38l
 Mst4 recombinant protein  >2 publications with Mob1b and Mst4
 Stk25 recombinant protein  >1 publications with Mob1b and Stk25

Pathways associated with Mob1b recombinant protein

 Products by Pathway  Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hippo Pathway antibodies  Signaling By Hippo Pathway Diagram

Diseases associated with Mob1b recombinant protein

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >2 publications with Mob1b and Lung Neoplasms
 Genomic Instability Antibodies  >1 publications with Mob1b and Genomic Instability
 Carcinoma, Hepatocellular Antibodies  >1 publications with Mob1b and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >1 publications with Mob1b and Cell Transformation, Neoplastic
 Skin Neoplasms Antibodies  >1 publications with Mob1b and Skin Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with Mob1b and Congenital Abnormalities

Organs/Tissues associated with Mob1b recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with Mob1b and Lung
 Thymus Antibodies  >1 publications with Mob1b and Thymus
 Pancreas Antibodies  >1 publications with Mob1b and Pancreas
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