Human KIAA0226 Recombinant Protein – Cat# MBS1335276

Run Domain Beclin-1 Interacting and Cystein-Rich Containing Protein (KIAA0226) Human Recombinant Protein

Name: KIAA0226 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1335276
Price: 1315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1335276

MBS1335276 is a recombinant protein targeting KIAA0226. Also known as Recombinant Human Run domain Beclin-1 interacting and cystein-rich containing protein (KIAA0226) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1315 / 0.5 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Run domain Beclin-1 interacting and cystein-rich containing protein (KIAA0226), Recombinant Protein

Full Product Name

Recombinant Human Run domain Beclin-1 interacting and cystein-rich containing protein (KIAA0226) , partial

Product Gene Name

KIAA0226 recombinant protein

Product Synonym Gene Name

KIAA0226

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

102,506 Da

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

613516

3D Structure

ModBase 3D Structure for Q92622

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KIAA0226 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KIAA0226. It may not necessarily be applicable to this product.

NCBI GI #

224548938

NCBI GeneID

9711

NCBI Accession #

NP_001139114.1

UniProt Primary Accession #

Q92622

UniProt Secondary Accession #

Q96CK5

UniProt Related Accession #

Q92622

GenBank Nucleotide #

NM_001145642.4

NCBI Official Full Name

run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform 1

NCBI Official Synonym Full Names

RUN and cysteine rich domain containing beclin 1 interacting protein

NCBI Official Symbol

RUBCN

NCBI Official Synonym Symbols

SCAR15; RUBICON; KIAA0226

UniProt Protein Name

Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

UniProt Synonym Protein Names

Beclin-1 associated RUN domain containing protein; Baron

UniProt Gene Name

RUBCN

UniProt Synonym Gene Names

Rubicon; Baron

NCBI Protein Information

run domain Beclin-1-interacting and cysteine-rich domain-containing protein

NCBI Summary for KIAA0226

The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

UniProt Comments for KIAA0226

Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745).

Research Articles on KIAA0226

1. HCV, by differentially inducing the expression of Rubicon and UVRAG, temporally regulated the autophagic flux to enhance its replication.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with KIAA0226 recombinant protein

Disease Name	Pubmed Publications
Ataxia Antibodies	>2 publications with KIAA0226 and Ataxia

Organs/Tissues associated with KIAA0226 recombinant protein

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>1 publications with KIAA0226 and Intestine
Brain Antibodies	>1 publications with KIAA0226 and Brain