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Doublesex- and Mab-3-Related Transcription Factor 1 (DMRT1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1335443

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key… More details

$1105 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Doublesex- and mab-3-related transcription factor 1 (DMRT1), Recombinant Protein
Full Product Name
Recombinant Human Doublesex- and mab-3-related transcription factor 1 (DMRT1)
Product Gene Name
DMRT1 recombinant protein
Product Synonym Gene Name
DMRT1
Sequence
MPNDEAFSKP STPSEAPHAP GVPPQGRAGG FGKASGALVG AASGSSAGGS SRGGGSGSGA SDLGAGSKKS PRLPKCARCR NHGYASPLKG HKRFCMWRDC QCKKCNLIAE RQRVMAAQVA LRRQQAQEEE LGISHPIPLP SAAELLVKRE NNGSNPCLMT ECSGTSQPPP ASVPTTAASE GRMVIQDIPA VTSRGHVENT PDLVSDSTYY SSFYQPSLFP YYNNLYNCPQ YSMALAADSA SGEVGNPLGG SPVKNSLRGL PGPYVPGQTG NQWQMKNMEN RHAMSSQYRM HSYYPPPSYL GQSVPQFFTF EDAPSYPEAR ASVFSPPSSQ DSGLVSLSSS SPISNKSTKA VLECEPASEP SSFTVTPVIE EDE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
18,325 Da
Sequence Positions
1-373, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
154230
3D Structure
ModBase 3D Structure for Q9Y5R6
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DMRT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DMRT1 purchase

MBS1335443 is a recombinant protein targeting DMRT1. Also known as Recombinant Human Doublesex- and mab-3-related transcription factor 1 (DMRT1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for DMRT1. It may not necessarily be applicable to this product.

NCBI GI #
62241026
NCBI GeneID
1761
NCBI Accession #
NP_068770.2
UniProt Primary Accession #
Q9Y5R6
UniProt Secondary Accession #
Q6T1H8; Q6T1H9; Q8IW77; B2R913
UniProt Related Accession #
Q9Y5R6
GenBank Nucleotide #
NM_021951.2
NCBI Official Full Name
doublesex- and mab-3-related transcription factor 1
NCBI Official Synonym Full Names
doublesex and mab-3 related transcription factor 1
NCBI Official Symbol
DMRT1
NCBI Official Synonym Symbols
DMT1; CT154
UniProt Protein Name
Doublesex- and mab-3-related transcription factor 1
UniProt Synonym Protein Names
DM domain expressed in testis protein 1
Protein Family
Doublesex and mab-3 related transcription factor
UniProt Gene Name
DMRT1
UniProt Synonym Gene Names
DMT1
NCBI Protein Information
doublesex- and mab-3-related transcription factor 1

UniProt Comments for DMRT1

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis ().
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Research Articles on DMRT1

1. DMRT1 might influence sex-specific patterns of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential involvement in hormone or immune cell regulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DMRT1 recombinant protein

 Reference Product  PubMed Publications
 SOX9 recombinant protein  >96 publications with DMRT1 and SOX9
 FOXL2 recombinant protein  >77 publications with DMRT1 and FOXL2
 SRY recombinant protein  >66 publications with DMRT1 and SRY
 AMH recombinant protein  >50 publications with DMRT1 and AMH
 NR0B1 recombinant protein  >14 publications with DMRT1 and NR0B1
 SOX2 recombinant protein  >14 publications with DMRT1 and SOX2
 SOX3 recombinant protein  >13 publications with DMRT1 and SOX3
 DOCK8 recombinant protein  >6 publications with DMRT1 and DOCK8
 LHX9 recombinant protein  >5 publications with DMRT1 and LHX9
 KANK1 recombinant protein  >5 publications with DMRT1 and KANK1

Diseases associated with DMRT1 recombinant protein

 Disease Name  Pubmed Publications
 Urogenital Abnormalities Antibodies  >46 publications with DMRT1 and Urogenital Abnormalities
 Chromosome Aberrations Antibodies  >24 publications with DMRT1 and Chromosome Aberrations
 Neoplasms, Germ Cell and Embryonal Antibodies  >24 publications with DMRT1 and Neoplasms, Germ Cell and Embryonal
 Testicular Neoplasms Antibodies  >21 publications with DMRT1 and Testicular Neoplasms
 Carcinoma Antibodies  >14 publications with DMRT1 and Carcinoma
 Infertility, Male Antibodies  >10 publications with DMRT1 and Infertility, Male
 Infertility, Female Antibodies  >5 publications with DMRT1 and Infertility, Female
 Liver Diseases Antibodies  >3 publications with DMRT1 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with DMRT1 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >2 publications with DMRT1 and Kidney Diseases

Organs/Tissues associated with DMRT1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >226 publications with DMRT1 and Testis
 Brain Antibodies  >37 publications with DMRT1 and Brain
 Connective Tissue Antibodies  >3 publications with DMRT1 and Connective Tissue
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