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NEDD8-Activating Enzyme E1 Regulatory Subunit (NAE1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1335788

This protein binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer s disease. In addition, the encoded… More details

$1340 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NEDD8-activating enzyme E1 regulatory subunit (Nae1), Recombinant Protein
Full Product Name
Recombinant Mouse NEDD8-activating enzyme E1 regulatory subunit (Nae1)
Product Gene Name
Nae1 recombinant protein
Product Synonym Gene Name
Nae1
Sequence
AQPGKILKEQ KYDRQLRLWG DHGQEALESA HVCLINATAT GTEILKNLVL PGIGSFTIID GNLVSGEDAG NNFFLQKSSI GKNRAQAAME FLQELNSDVS GSFVEESPEN LLDNDPSFFC RFTIVVATQL LESTLLRLAD VLWNSQIPLL ICRTYGLVGY MRIIIKEHPV IESHPDNALE DLRLDKPFPE LREHLQSYDL DHMEKKDHSH TPWIVIIAKY LAQWYNETNG RIPKSYKEKE DFRDLIRQGI LKNENGAPED EENFEEAIKN VNTALNTTQI PSSIEDIFND DRCINITKQT PTFWILARAL KEFVAKEGQG NLPVRGTIPD MIADSNKYIK LQNVYREKAK KDAAAVGNHV AKLLQSVGQA PESISEKELK LLCSNSAFLR VVRCRSLAEE YGLDTVNKDE IISSMDNPDN EIVLYLMLRA VDRFHKQHGR YPGVSNYQVE EDIGKLKSCL TGFLQEYGLS VMVKDDYVHE FCRYGAAEPH TIAAFLGGAA AQEVIKIITK QFVIFNNTYI YSGMSQTSAT FQL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
60,274 Da
Sequence Positions
2-534, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8VBW6
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nae1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nae1 purchase

MBS1335788 is a recombinant protein targeting Nae1. Also known as Recombinant Mouse NEDD8-activating enzyme E1 regulatory subunit (Nae1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Nae1. It may not necessarily be applicable to this product.

NCBI GI #
21450341
NCBI GeneID
234664
NCBI Accession #
NP_659180.1
UniProt Primary Accession #
Q8VBW6
UniProt Secondary Accession #
Q8CFL6
UniProt Related Accession #
Q8VBW6
GenBank Nucleotide #
NM_144931.3
NCBI Official Full Name
NEDD8-activating enzyme E1 regulatory subunit
NCBI Official Synonym Full Names
NEDD8 activating enzyme E1 subunit 1
NCBI Official Symbol
Nae1
NCBI Official Synonym Symbols
59kDa; Appbp1
UniProt Protein Name
NEDD8-activating enzyme E1 regulatory subunit
UniProt Synonym Protein Names
Amyloid beta precursor protein-binding protein 1, 59 kDa; APP-BP1; Amyloid protein-binding protein 1
Protein Family
NEDD8-activating enzyme E1 regulatory
UniProt Gene Name
Nae1
UniProt Synonym Gene Names
Appbp1; APP-BP1
NCBI Protein Information
NEDD8-activating enzyme E1 regulatory subunit

UniProt Comments for Nae1

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation ().
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Research Articles on Nae1

1. APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Nae1 recombinant protein

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram

Diseases associated with Nae1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with Nae1 and Neoplasms
 Breast Neoplasms Antibodies  >1 publications with Nae1 and Breast Neoplasms

Organs/Tissues associated with Nae1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with Nae1 and Kidney
 Heart Antibodies  >1 publications with Nae1 and Heart
 Skin Antibodies  >1 publications with Nae1 and Skin
 Brain Antibodies  >1 publications with Nae1 and Brain
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