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Mediator of RNA Polymerase II Transcription Subunit 24 (MED24) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1338262

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional… More details

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Product Overview

Online Datasheet in PDF
Product Name
Mediator of RNA polymerase II transcription subunit 24 (Med24), Recombinant Protein
Full Product Name
Recombinant Mouse Mediator of RNA polymerase II transcription subunit 24 (Med24) , partial
Product Gene Name
Med24 recombinant protein
Product Synonym Gene Name
Med24
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
83,879 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q99K74
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Med24 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Med24 purchase

MBS1338262 is a recombinant protein targeting Med24. Also known as Recombinant Mouse Mediator of RNA polymerase II transcription subunit 24 (Med24) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Med24. It may not necessarily be applicable to this product.

NCBI GI #
119220579
NCBI GeneID
23989
NCBI Accession #
NP_035999.2
UniProt Primary Accession #
Q99K74
UniProt Secondary Accession #
Q8R004; Q9D277; Q9WVF1; A3KFP0
UniProt Related Accession #
Q99K74
GenBank Nucleotide #
NM_011869.2
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 24
NCBI Official Synonym Full Names
mediator complex subunit 24
NCBI Official Symbol
Med24
NCBI Official Synonym Symbols
Gse2; 911GSE; Pparb2; R75526; Thrap4; DRIP100; Pparbp2; Trap100; AU040102; AW547152; D11Ertd307e
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 24
UniProt Synonym Protein Names
Mediator complex subunit 24; Thyroid hormone receptor-associated protein 4; Thyroid hormone receptor-associated protein complex 100 kDa component; Trap100; mTRAP100
Protein Family
Mediator of RNA polymerase II transcription
UniProt Gene Name
Med24
UniProt Synonym Gene Names
D11Ertd307e; Thrap4; Trap100; Trap100; mTRAP100
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 24

NCBI Summary for Med24

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
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UniProt Comments for Med24

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (). Required for basal and activator-dependent transcription.
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Research Articles on Med24

1. functional communications between the MED1 subunit and the MED24-containing submodule that mediate estrogen receptor functions and growth of both normal mammary epithelial cells and breast carcinoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Med24 recombinant protein

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with Med24 recombinant protein

 Disease Name  Pubmed Publications
 Death Antibodies  >3 publications with Med24 and Death
 Breast Neoplasms Antibodies  >3 publications with Med24 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with Med24 and Kidney Diseases
 Congenital Abnormalities Antibodies  >1 publications with Med24 and Congenital Abnormalities
 Mammary Neoplasms, Animal Antibodies  >1 publications with Med24 and Mammary Neoplasms, Animal
 Prostatic Diseases Antibodies  >1 publications with Med24 and Prostatic Diseases
 Neoplasm Metastasis Antibodies  >1 publications with Med24 and Neoplasm Metastasis

Organs/Tissues associated with Med24 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with Med24 and Liver
 Kidney Antibodies  >1 publications with Med24 and Kidney
 Mammary Gland Antibodies  >1 publications with Med24 and Mammary Gland
 Eye Antibodies  >1 publications with Med24 and Eye
 Embryonic Tissue Antibodies  >1 publications with Med24 and Embryonic Tissue
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