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Mediator of RNA Polymerase II Transcription Subunit 15 (MED15) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1338914

This protein is a subunit of the multiprotein complexes PC2 and ARCDRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region… More details

$1670 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Mediator of RNA polymerase II transcription subunit 15 (MED15), Recombinant Protein
Full Product Name
Recombinant Human Mediator of RNA polymerase II transcription subunit 15 (MED15)
Product Gene Name
MED15 recombinant protein
Product Synonym Gene Name
MED15
Sequence
MDVSGQETDW RSTAFRQKLV SQIEDAMRKA GVAHSKSSKD MESHVFLKAK TRDEYLSLVA RLIIHFRDIH NKKSQASVSD PMNALQSLTG GPAAGAAGIG MPPRGPGQSL GGMGSLGAMG QPMSLSGQPP PGTSGMAPHS MAVVSTATPQ TQLQLQQVAL QQQQQQQQFQ QQQQAALQQQ QQQQQQQQFQ AQQSAMQQQF QAVVQQQQQL QQQQQQQQHL IKLHHQNQQQ IQQQQQQLQR IAQLQLQQQQ QQQQQQQQQQ QQALQAQPPI QQPPMQQPQP PPSQALPQQL QQMHHTQHHQ PPPQPQQPPV AQNQPSQLPP QSQTQPLVSQ AQALPGQMLY TQPPLKFVRA PMVVQQPPVQ PQVQQQQTAV QTAQAAQMVA PGVQMITEAL AQGGMHIRAR FPPTTAVSAI PSSSIPLGRQ PMAQVSQSSL PMLSSPSPGQ QVQTPQSMPP PPQPSPQPGQ PSSQPNSNVS SGPAPSPSSF LPSPSPQPSQ SPVTARTPQN FSVPSPGPLN TPVNPSSVMS PAGSSQAEEQ QYLDKLKQLS KYIEPLRRMI NKIDKNEDRK KDLSKMKSLL DILTDPSKRC PLKTLQKCEI ALEKLKNDMA VPTPPPPPVP PTKQQYLCQP LLDAVLANIR SPVFNHSLYR TFVPAMTAIH GPPITAPVVC TRKRRLEDDE RQSIPSVLQG EVARLDPKFL VNLDPSHCSN NGTVHLICKL DDKDLPSVPP LELSVPADYP AQSPLWIDRQ WQYDANPFLQ SVHRCMTSRL LQLPDKHSVT ALLNTWAQSV HQACLSAA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
75,927 Da
Sequence Positions
1-788, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
607372
3D Structure
ModBase 3D Structure for Q96RN5
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MED15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MED15 purchase

MBS1338914 is a recombinant protein targeting MED15. Also known as Recombinant Human Mediator of RNA polymerase II transcription subunit 15 (MED15). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for MED15. It may not necessarily be applicable to this product.

NCBI GI #
51477700
NCBI GeneID
51586
NCBI Accession #
NP_001003891.1
UniProt Primary Accession #
Q96RN5
UniProt Secondary Accession #
O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q9P1T3; D3DX31; D3DX32
UniProt Related Accession #
Q96RN5
GenBank Nucleotide #
NM_001003891.2
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 15 isoform a
NCBI Official Synonym Full Names
mediator complex subunit 15
NCBI Official Symbol
MED15
NCBI Official Synonym Symbols
TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 15
UniProt Synonym Protein Names
Activator-recruited cofactor 105 kDa component; ARC105; CTG repeat protein 7a; Mediator complex subunit 15; Positive cofactor 2 glutamine/Q-rich-associated protein; PC2 glutamine/Q-rich-associated protein; TPA-inducible gene 1 protein; TIG-1; Trinucleotide repeat-containing gene 7 protein
Protein Family
Mediator of RNA polymerase II transcription
UniProt Gene Name
MED15
UniProt Synonym Gene Names
ARC105; CTG7A; PCQAP; TIG1; TNRC7; ARC105; PC2 glutamine/Q-rich-associated protein; TIG-1
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 15

NCBI Summary for MED15

The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
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UniProt Comments for MED15

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
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Research Articles on MED15

1. MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K/Akt/mTOR signaling pathway in prostate cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MED15 recombinant protein

 Reference Product  PubMed Publications
 TRIM11 recombinant protein  >1 publications with MED15 and TRIM11
 SMAD3 recombinant protein  >1 publications with MED15 and SMAD3
 SMAD2 recombinant protein  >1 publications with MED15 and SMAD2

Pathways associated with MED15 recombinant protein

 Products by Pathway  Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with MED15 recombinant protein

 Disease Name  Pubmed Publications
 Pain Antibodies  >7 publications with MED15 and Pain
 Arthritis, Rheumatoid Antibodies  >4 publications with MED15 and Arthritis, Rheumatoid
 Inflammation Antibodies  >3 publications with MED15 and Inflammation
 Colitis Antibodies  >1 publications with MED15 and Colitis
 Gastritis Antibodies  >1 publications with MED15 and Gastritis
 Liver Diseases Antibodies  >1 publications with MED15 and Liver Diseases
 Adenomatous Polyposis Coli Antibodies  >1 publications with MED15 and Adenomatous Polyposis Coli
 Uterine Neoplasms Antibodies  >1 publications with MED15 and Uterine Neoplasms
 Drug-Induced Liver Injury Antibodies  >1 publications with MED15 and Drug-Induced Liver Injury
 Kidney Diseases Antibodies  >1 publications with MED15 and Kidney Diseases

Organs/Tissues associated with MED15 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >19 publications with MED15 and Stomach
 Blood Antibodies  >8 publications with MED15 and Blood
 Intestine Antibodies  >6 publications with MED15 and Intestine
 Liver Antibodies  >4 publications with MED15 and Liver
 Embryonic Tissue Antibodies  >4 publications with MED15 and Embryonic Tissue
 Bone Antibodies  >3 publications with MED15 and Bone
 Kidney Antibodies  >2 publications with MED15 and Kidney
 Nerve Antibodies  >1 publications with MED15 and Nerve
 Connective Tissue Antibodies  >1 publications with MED15 and Connective Tissue
 Placenta Antibodies  >1 publications with MED15 and Placenta
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