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DNA-Directed RNA Polymerase II Subunit GRINL1A, Isoforms 4/5 (POLR2M) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1338920

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as… More details

$800 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 (POLR2M), Recombinant Protein
Full Product Name
Recombinant Human DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 (POLR2M)
Product Gene Name
POLR2M recombinant protein
Product Synonym Gene Name
POLR2M
Sequence
MATPARAPES PPSADPALVA GPAEEAECPP PRQPQPAQNV LAAPRLRAPS SRGLGAAEFG GAAGNVEAPG ETFAQRVSWG PAESPPGSFS SSSLGAPLPS RTLFPSLEGD FDSVTFASVL RASGRRACCG RAVPLPGQKI HLQIARQR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
64,046 Da
Sequence Positions
1-148, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606485
3D Structure
ModBase 3D Structure for Q6EEV4
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of POLR2M recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POLR2M purchase

MBS1338920 is a recombinant protein targeting POLR2M. Also known as Recombinant Human DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 (POLR2M). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for POLR2M. It may not necessarily be applicable to this product.

NCBI GI #
70166832
NCBI GeneID
81488
NCBI Accession #
NP_001018112.1
UniProt Primary Accession #
Q6EEV4
UniProt Secondary Accession #
Q6EEV7
UniProt Related Accession #
P0CAP2; Q6EEV4
GenBank Nucleotide #
NM_001018102.2
NCBI Official Full Name
protein GRINL1A isoform 2
NCBI Official Synonym Full Names
RNA polymerase II subunit M
NCBI Official Symbol
POLR2M
NCBI Official Synonym Symbols
GCOM1; Gdown; Gdown1; GRINL1A
UniProt Protein Name
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5
UniProt Synonym Protein Names
DNA-directed RNA polymerase II subunit M, isoforms 4/5
Protein Family
DNA-directed RNA polymerase
UniProt Gene Name
POLR2M
UniProt Synonym Gene Names
GRINL1A
NCBI Protein Information
protein GRINL1A

NCBI Summary for POLR2M

This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]
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UniProt Comments for POLR2M

MiscellaneousThe adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.

Research Articles on POLR2M

1. The relatively slow functional loading of Gdown1 in the presence of TFIIF.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with POLR2M recombinant protein

 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >1 publications with POLR2M and Drug Toxicity

Organs/Tissues associated with POLR2M recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with POLR2M and Heart
 Brain Antibodies  >1 publications with POLR2M and Brain
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