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Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1339081

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. More details

$1570 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Connector enhancer of kinase suppressor of ras 1 (CNKSR1), Recombinant Protein
Full Product Name
Recombinant Human Connector enhancer of kinase suppressor of ras 1 (CNKSR1)
Product Gene Name
CNKSR1 recombinant protein
Product Synonym Gene Name
CNKSR1
Sequence
MEPVETWTPG KVATWLRGLD DSLQDYPFED WQLPGKNLLQ LCPQSLEALA VRSLGHQELI LGGVEQLQAL SSRLQTENLQ SLTEGLLGAT HDFQSIVQGC LGDCAKTPID VLCAAVELLH EADALLFWLS RYLFSHLNDF SACQEIRDLL EELSQVLHED GPAAEKEGTV LRICSHVAGI CHNILVCCPK ELLEQKAVLE QVQLDSPLGL EIHTTSNCQH FVSQVDTQVP TDSRLQIQPG DEVVQINEQV VVREERDMVG WPRKNMVREL LREPAGLSLV LKKIPIPETP PQTPPQVLDS PHQRSPSLSL APLSPRAPSE DVFAFDLSSN PSPGPSPAWT DSASLGPEPL PIPPEPPAIL PAGVAGTPGL PESPDKSPVG RKKSKGLATR LSRRRVSCRE LGRPDCDGWL LLRKAPGGFM GPRWRRRWFV LKGHTLYWYR QPQDEKAEGL INVSNYSLES GHDQKKKYVF QLTHDVYKPF IFAADTLTDL SMWVRHLITC ISKYQSPGRA PPPREEDCYS ETEAEDPDDE AGSHSASPSP AQAGSPLHGD TSPAATPTQR SPRTSFGSLT DSSEEALEGM VRGLRQGGVS LLGQPQPLTQ EQWRSSFMRR NRDPQLNERV HRVRALQSTL KAKLQELQVL EEVLGDPELT GEKFRQWKEQ NRELYSEGLG AWGVAQAEGS SHILTSDSTE QSPHSLPSDP EEHSHLCPLT SESSLRPPDL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
78,790 Da
Sequence Positions
1-720, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
603272
3D Structure
ModBase 3D Structure for Q969H4
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CNKSR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNKSR1 purchase

MBS1339081 is a recombinant protein targeting CNKSR1. Also known as Recombinant Human Connector enhancer of kinase suppressor of ras 1 (CNKSR1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CNKSR1. It may not necessarily be applicable to this product.

NCBI GI #
663071014
NCBI GeneID
10256
NCBI Accession #
NP_001284576.1
UniProt Primary Accession #
Q969H4
UniProt Secondary Accession #
O95381; B1AMW9
UniProt Related Accession #
Q969H4
GenBank Nucleotide #
NM_001297647.1
NCBI Official Full Name
connector enhancer of kinase suppressor of ras 1 isoform 2
NCBI Official Synonym Full Names
connector enhancer of kinase suppressor of Ras 1
NCBI Official Symbol
CNKSR1
NCBI Official Synonym Symbols
CNK; CNK1
UniProt Protein Name
Connector enhancer of kinase suppressor of ras 1
UniProt Synonym Protein Names
CNK homolog protein 1; CNK1; hCNK1; Connector enhancer of KSR-like
Protein Family
Connector enhancer of kinase suppressor of ras
UniProt Gene Name
CNKSR1
UniProt Synonym Gene Names
CNK1; Connector enhancer of KSR 1; CNK1; hCNK1
NCBI Protein Information
connector enhancer of kinase suppressor of ras 1

NCBI Summary for CNKSR1

This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for CNKSR1

May function as an adapter protein or regulator of Ras signaling pathways.

Research Articles on CNKSR1

1. The findings reveal SAM domain-dependent oligomerization by AKT as a switch for CNK1 activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CNKSR1 recombinant protein

 Reference Product  PubMed Publications
 KSR1 recombinant protein  >3 publications with CNKSR1 and KSR1
 RHOA recombinant protein  >1 publications with CNKSR1 and RHOA
 RASSF1 recombinant protein  >1 publications with CNKSR1 and RASSF1

Pathways associated with CNKSR1 recombinant protein

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
 Downstream Signaling Of Activated FGFR2 Pathway antibodies  Downstream Signaling Of Activated FGFR2 Pathway Diagram
 Downstream Signaling Of Activated FGFR3 Pathway antibodies  Downstream Signaling Of Activated FGFR3 Pathway Diagram

Diseases associated with CNKSR1 recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with CNKSR1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with CNKSR1 and Carcinoma, Hepatocellular
 Uterine Cervical Neoplasms Antibodies  >1 publications with CNKSR1 and Uterine Cervical Neoplasms
 Disease Models, Animal Antibodies  >1 publications with CNKSR1 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with CNKSR1 and Inflammation

Organs/Tissues associated with CNKSR1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with CNKSR1 and Liver
 Heart Antibodies  >1 publications with CNKSR1 and Heart
 Embryonic Tissue Antibodies  >1 publications with CNKSR1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with CNKSR1 and Kidney
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