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Vacuolar Protein-Sorting-Associated Protein 36 (VPS36) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1340696

MBS1340696 is a recombinant protein targeting VPS36. Also known as Recombinant Human Vacuolar protein-sorting-associated protein 36 (VPS36). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1120 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Vacuolar protein-sorting-associated protein 36 (VPS36), Recombinant Protein
Full Product Name
Recombinant Human Vacuolar protein-sorting-associated protein 36 (VPS36)
Product Gene Name
VPS36 recombinant protein
Product Synonym Gene Name
VPS36
Sequence
MDRFVWTSGL LEINETLVIQ QRGVRIYDGE EKIKFDAGTL LLSTHRLIWR DQKNHECCMA ILLSQIVFIE EQAAGIGKSA KIVVHLHPAP PNKEPGPFQS SKNSYIKLSF KEHGQIEFYR RLSEEMTQRR WENMPVSQSL QTNRGPQPGR IRAVGIVGIE RKLEEKRKET DKNISEAFED LSKLMIKAKE MVELSKSIAN KIKDKQGDIT EDETIRFKSY LLSMGIANPV TRETYGSGTQ YHMQLAKQLA GILQVPLEER GGIMSLTEVY CLVNRARGME LLSPEDLVNA CKMLEALKLP LRLRVFDSGV MVIELQSHKE EEMVASALET VSEKGSLTSE EFAKLVGMSV LLAKERLLLA EKMGHLCRDD SVEGLRFYPN LFMTQS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
36,958 Da
Sequence Positions
1-386, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
610903
3D Structure
ModBase 3D Structure for Q86VN1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of VPS36 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS36. It may not necessarily be applicable to this product.

NCBI GI #
532164692
NCBI GeneID
51028
NCBI Accession #
NP_001269098.1
UniProt Primary Accession #
Q86VN1
UniProt Secondary Accession #
Q3ZCV7; Q5H9S1; Q5VXB6; Q9H8Z5; Q9Y3E3; A8K125
UniProt Related Accession #
Q86VN1
GenBank Nucleotide #
NM_001282169.1
NCBI Official Full Name
vacuolar protein-sorting-associated protein 36 isoform 3
NCBI Official Synonym Full Names
vacuolar protein sorting 36 homolog
NCBI Official Symbol
VPS36
NCBI Official Synonym Symbols
EAP45; C13orf9; CGI-145
UniProt Protein Name
Vacuolar protein-sorting-associated protein 36
UniProt Synonym Protein Names
ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36
Protein Family
Vacuolar protein sorting-associated protein
UniProt Gene Name
VPS36
UniProt Synonym Gene Names
C13orf9; EAP45
NCBI Protein Information
vacuolar protein-sorting-associated protein 36

NCBI Summary for VPS36

This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
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UniProt Comments for VPS36

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
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Research Articles on VPS36

1. RAB27A, RAB27B and VPS36 are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B and VPS36, with RAB27A and RAB27B being dependent on VPS36.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with VPS36 recombinant protein

 Reference Product  PubMed Publications
 VPS25 recombinant protein  >10 publications with VPS36 and VPS25
 SNF8 recombinant protein  >9 publications with VPS36 and SNF8
 VPS28 recombinant protein  >4 publications with VPS36 and VPS28
 VPS24 recombinant protein  >1 publications with VPS36 and VPS24

Pathways associated with VPS36 recombinant protein

 Products by Pathway  Pathway Diagram
 ESCRT-II Complex Pathway antibodies  ESCRT-II Complex Pathway Diagram
 ESCRT-II Complex Pathway antibodies  ESCRT-II Complex Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram

Diseases associated with VPS36 recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with VPS36 and Kidney Diseases
 Immune System Diseases Antibodies  >1 publications with VPS36 and Immune System Diseases
 Congenital Abnormalities Antibodies  >1 publications with VPS36 and Congenital Abnormalities
 Death Antibodies  >1 publications with VPS36 and Death
 Cell Transformation, Neoplastic Antibodies  >1 publications with VPS36 and Cell Transformation, Neoplastic

Organs/Tissues associated with VPS36 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with VPS36 and Kidney
 Blood Antibodies  >2 publications with VPS36 and Blood
 Liver Antibodies  >1 publications with VPS36 and Liver
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