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Linker for Activation of T-Cells Family Member 2 (LAT2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1344772

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same… More details

$1360 / 0.5 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Linker for activation of T-cells family member 2 (LAT2), Recombinant Protein
Full Product Name
Recombinant Human Linker for activation of T-cells family member 2 (LAT2), partial
Product Gene Name
LAT2 recombinant protein
Product Synonym Gene Name
LAT2
Sequence
MSSGTELLWP GAALLVLLGV AASLCVRCSR PGAKRSEKIY QQRSLREDQQ SFTGSRTYSL VGQAWPGPLA DMAPTRKDKL LQFYPSLEDP ASSRYQNFSK GSRHGSEEAY IDPIAMEYYN WGRFSKPPED DDANSYENVL ICKQKTTETG AQQEGIGGLC RGDLSLSLAL KTGPTSGLCP SASPEEDEES EDYQNSASIH QWRESRKVMG QLQREASPGP VGSPDEEDGE PDYVNGEVAA TEA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
12,255 Da
Sequence Positions
1-243
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605719
3D Structure
ModBase 3D Structure for Q9GZY6
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LAT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAT2 purchase

MBS1344772 is a recombinant protein targeting LAT2. Also known as Recombinant Human Linker for activation of T-cells family member 2 (LAT2), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for LAT2. It may not necessarily be applicable to this product.

NCBI GI #
14702182
NCBI GeneID
7462
NCBI Accession #
NP_054865.2
UniProt Primary Accession #
Q9GZY6
UniProt Secondary Accession #
Q9BXX8; Q9NZY9; A6NFK6; A8K209; A8K4F1; D3DXF9
UniProt Related Accession #
Q9GZY6
GenBank Nucleotide #
NM_014146.3
NCBI Official Full Name
linker for activation of T-cells family member 2
NCBI Official Synonym Full Names
linker for activation of T cells family member 2
NCBI Official Symbol
LAT2
NCBI Official Synonym Symbols
LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
UniProt Protein Name
Linker for activation of T-cells family member 2
UniProt Synonym Protein Names
Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein
Protein Family
Linker for activation of T-cells family
UniProt Gene Name
LAT2
UniProt Synonym Gene Names
LAB; NTAL; WBS15; WBSCR15; WBSCR5
NCBI Protein Information
linker for activation of T-cells family member 2

UniProt Comments for LAT2

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
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Research Articles on LAT2

1. The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LAT2 recombinant protein

 Reference Product  PubMed Publications
 LAT recombinant protein  >49 publications with LAT2 and LAT
 GRB2 recombinant protein  >14 publications with LAT2 and GRB2
 CBL recombinant protein  >4 publications with LAT2 and CBL
 GAB1 recombinant protein  >2 publications with LAT2 and GAB1
 BLNK recombinant protein  >1 publications with LAT2 and BLNK
 SOS1 recombinant protein  >1 publications with LAT2 and SOS1

Pathways associated with LAT2 recombinant protein

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Role Of LAT2/NTAL/LAB On Calcium Mobilization Pathway antibodies  Role Of LAT2/NTAL/LAB On Calcium Mobilization Pathway Diagram

Diseases associated with LAT2 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with LAT2 and Inflammation
 Liver Diseases Antibodies  >7 publications with LAT2 and Liver Diseases
 Disease Models, Animal Antibodies  >7 publications with LAT2 and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with LAT2 and Kidney Diseases
 Brain Diseases Antibodies  >5 publications with LAT2 and Brain Diseases
 Necrosis Antibodies  >5 publications with LAT2 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >3 publications with LAT2 and Carcinoma, Hepatocellular
 Death Antibodies  >3 publications with LAT2 and Death
 Liver Neoplasms Antibodies  >3 publications with LAT2 and Liver Neoplasms
 Edema Antibodies  >2 publications with LAT2 and Edema

Organs/Tissues associated with LAT2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >57 publications with LAT2 and Blood
 Brain Antibodies  >45 publications with LAT2 and Brain
 Kidney Antibodies  >33 publications with LAT2 and Kidney
 Intestine Antibodies  >29 publications with LAT2 and Intestine
 Muscle Antibodies  >14 publications with LAT2 and Muscle
 Placenta Antibodies  >13 publications with LAT2 and Placenta
 Liver Antibodies  >13 publications with LAT2 and Liver
 Eye Antibodies  >9 publications with LAT2 and Eye
 Spleen Antibodies  >5 publications with LAT2 and Spleen
 Lung Antibodies  >5 publications with LAT2 and Lung
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