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SIN3B Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS001345

MBS001345 is an antibody targeting SIN3B. Also known as Rabbit SIN3B Antibody. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SIN3B, Antibody
Full Product Name
Rabbit SIN3B Antibody
Product Gene Name
anti-SIN3B antibody
Host
Rabbit
Species Reactivity
Human
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Molecular Weight
133,066 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (16940209..16991164). Location: 19p13.11
OMIM
607777
3D Structure
ModBase 3D Structure for O75182
Applications Tested/Suitable for anti-SIN3B antibody
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

Other Notes

Small volumes of anti-SIN3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SIN3B. It may not necessarily be applicable to this product.

NCBI GI #
52138513
NCBI GeneID
23309
NCBI Accession #
NP_056075.1
UniProt Primary Accession #
O75182
UniProt Secondary Accession #
Q2NL91; Q68GC2; Q6P4B8; Q8TB34; Q9BSC8
UniProt Related Accession #
O75182
GenBank Nucleotide #
NM_015260.2
NCBI Official Full Name
paired amphipathic helix protein Sin3b
NCBI Official Synonym Full Names
SIN3 transcription regulator homolog B (yeast)
NCBI Official Symbol
SIN3B
UniProt Protein Name
Paired amphipathic helix protein Sin3b
UniProt Synonym Protein Names
Histone deacetylase complex subunit Sin3b; Transcriptional corepressor Sin3b
Protein Family
Paired amphipathic helix protein
UniProt Gene Name
SIN3B
UniProt Synonym Gene Names
KIAA0700
UniProt Entry Name
SIN3B_HUMAN
NCBI Protein Information
paired amphipathic helix protein Sin3b; transcriptional corepressor Sin3b; SIN3 homolog B, transcription regulator; SIN3 homolog B, transcriptional regulator; histone deacetylase complex subunit Sin3b

UniProt Comments for SIN3B

SIN3B: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: nucleoplasm; Y chromosome; XY body; autosome; Sin3 complex; X chromosome; cytoplasm; nucleus

Molecular Function: protein binding; chromatin binding; histone deacetylase activity

Biological Process: cardiac muscle development; skeletal muscle development; transcription, DNA-dependent; histone deacetylation; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on SIN3B

1. the essential role of Sin3B as an important associate of p53 in mediating the cellular responses to stress and in the transcriptional repression of genes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SIN3B antibody

 Reference Product  PubMed Publications
 HDAC1 antibody  >10 publications with SIN3B and HDAC1
 REST antibody  >4 publications with SIN3B and REST
 MAD1L1 antibody  >4 publications with SIN3B and MAD1L1
 MXI1 antibody  >1 publications with SIN3B and MXI1
 IKZF1 antibody  >1 publications with SIN3B and IKZF1

Pathways associated with anti-SIN3B antibody

 Products by Pathway  Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram

Diseases associated with anti-SIN3B antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >1 publications with SIN3B and Neoplasm Metastasis
 Musculoskeletal Diseases Antibodies  >1 publications with SIN3B and Musculoskeletal Diseases
 Breast Neoplasms Antibodies  >1 publications with SIN3B and Breast Neoplasms
 Adenocarcinoma Antibodies  >1 publications with SIN3B and Adenocarcinoma
 Mammary Neoplasms, Animal Antibodies  >1 publications with SIN3B and Mammary Neoplasms, Animal
 Kidney Diseases Antibodies  >1 publications with SIN3B and Kidney Diseases

Organs/Tissues associated with anti-SIN3B antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with SIN3B and Liver
 Nerve Antibodies  >3 publications with SIN3B and Nerve
 Muscle Antibodies  >3 publications with SIN3B and Muscle
 Brain Antibodies  >3 publications with SIN3B and Brain
 Heart Antibodies  >2 publications with SIN3B and Heart
 Eye Antibodies  >2 publications with SIN3B and Eye
 Embryonic Tissue Antibodies  >2 publications with SIN3B and Embryonic Tissue
 Ovary Antibodies  >1 publications with SIN3B and Ovary
 Epididymis Antibodies  >1 publications with SIN3B and Epididymis
 Kidney Antibodies  >1 publications with SIN3B and Kidney
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