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Meiotic Recombination Protein SPO11 (SPO11) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1345530

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5 end of DSBs and is essential for the… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Meiotic recombination protein SPO11 (SPO11), Recombinant Protein
Full Product Name
Recombinant Human Meiotic recombination protein SPO11 (SPO11)
Product Gene Name
SPO11 recombinant protein
Product Synonym Gene Name
SPO11
Sequence
MAFAPMGPEA SFFDVLDRHR ESLLAALRRG GREPPTGGSR LASSSEVLAS IENIIQDIIT SLARNEAPAF TIDNRSSWEN IKFEDSVGLQ MVSHCTTRKI KSDSPKSAQK FSLILKILSM IYKLVQSNTY ATKRDIYYTD SQLFGNQTVV DNIINDISCM LKVSRRSLHI LSTSKGLIAG NLRYIEEDGT KVNCTCGATA VAVPSNIQGI RNLVTDAKFV LIVEKDATFQ RLLDDNFCNK LSPCIMITGK GVPDLNTRLL VKKLWDTFHV PVFTLVDADP HGIEIMCIYK YGSMSMSFEA HHLTVPAIRW LGLLPSDLKR LNVPKDSLIP LTKRDQMKLD SILRRPYVTC QPFWRKEMEI MADSKMKAEI QALTFLSSDY LSRVYLPNKL KFGGWI
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
40,364 Da
Sequence Positions
1-396aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605114
3D Structure
ModBase 3D Structure for Q9Y5K1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SPO11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPO11 purchase

MBS1345530 is a recombinant protein targeting SPO11. Also known as Recombinant Human Meiotic recombination protein SPO11 (SPO11). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SPO11. It may not necessarily be applicable to this product.

NCBI GI #
6912680
NCBI GeneID
23626
NCBI Accession #
NP_036576.1
UniProt Primary Accession #
Q9Y5K1
UniProt Secondary Accession #
Q5TCI1; Q8N4V0; Q9NQM7; Q9NQM8
UniProt Related Accession #
Q9Y5K1
GenBank Nucleotide #
NM_012444.2
NCBI Official Full Name
meiotic recombination protein SPO11 isoform a
NCBI Official Synonym Full Names
SPO11, initiator of meiotic double stranded breaks
NCBI Official Symbol
SPO11
NCBI Official Synonym Symbols
CT35; TOPVIA; SPATA43
UniProt Protein Name
Meiotic recombination protein SPO11
UniProt Synonym Protein Names
Cancer/testis antigen 35; CT35
Protein Family
Meiosis-specific protein
UniProt Gene Name
SPO11
UniProt Synonym Gene Names
CT35
NCBI Protein Information
meiotic recombination protein SPO11

NCBI Summary for SPO11

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for SPO11

Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
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Research Articles on SPO11

1. SPO11 gene C631T polymorphism may contribute as a genetic factor susceptible to cause male infertility in Chinese.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SPO11 recombinant protein

 Reference Product  PubMed Publications
 RAD51 recombinant protein  >41 publications with SPO11 and RAD51
 RAD50 recombinant protein  >35 publications with SPO11 and RAD50
 ATM recombinant protein  >21 publications with SPO11 and ATM
 BRCA1 recombinant protein  >6 publications with SPO11 and BRCA1
 BRCA2 recombinant protein  >3 publications with SPO11 and BRCA2
 MRE11A recombinant protein  >2 publications with SPO11 and MRE11A
 RBBP8 recombinant protein  >1 publications with SPO11 and RBBP8
 TEX15 recombinant protein  >1 publications with SPO11 and TEX15

Pathways associated with SPO11 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Recombination Pathway antibodies  Meiotic Recombination Pathway Diagram

Diseases associated with SPO11 recombinant protein

 Disease Name  Pubmed Publications
 Infertility, Female Antibodies  >8 publications with SPO11 and Infertility, Female
 Death Antibodies  >6 publications with SPO11 and Death
 Kidney Diseases Antibodies  >2 publications with SPO11 and Kidney Diseases
 Ovarian Diseases Antibodies  >2 publications with SPO11 and Ovarian Diseases
 Gonadal Disorders Antibodies  >2 publications with SPO11 and Gonadal Disorders
 Prostatic Neoplasms Antibodies  >1 publications with SPO11 and Prostatic Neoplasms
 Embryo Loss Antibodies  >1 publications with SPO11 and Embryo Loss
 Prostatic Diseases Antibodies  >1 publications with SPO11 and Prostatic Diseases
 Atrophy Antibodies  >1 publications with SPO11 and Atrophy
 Sarcoma Antibodies  >1 publications with SPO11 and Sarcoma

Organs/Tissues associated with SPO11 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with SPO11 and Brain
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