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Keratin, Type I Cytoskeletal 17 (KRT17) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1345871

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. More details

$1195 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Keratin, type I cytoskeletal 17 (Krt17), Recombinant Protein
Full Product Name
Recombinant Rat Keratin, type I cytoskeletal 17 (Krt17)
Product Gene Name
Krt17 recombinant protein
Product Synonym Gene Name
Krt17
Sequence
MTTTIRQFTS SSSIKGSSGL GGGSSRTSCR LSGSLGAGSC RLGSASGLGS ALGGNSYSSC YSFGTGSGYG GNFGGVDGLL AGGEKATMQN LNDRLASYLD KVRALEEANT ELEVKIRDWY QKQAPGPARD YSAYYQTIED LKNKILVATV DNASILLQID NARLAADDFR TKFETEQALR MSVEADINGL RRVLDELTLA RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS RILSEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI SELRRTMQAL EIELQSQLSM KASLEGSLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKP KEPVTTRQVR TIVEEVQDGK VISSREQVHQ TTR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
48,123 Da
Sequence Positions
1-433, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6IFU8
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Krt17 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Krt17 purchase

MBS1345871 is a recombinant protein targeting Krt17. Also known as Recombinant Rat Keratin, type I cytoskeletal 17 (Krt17). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Krt17. It may not necessarily be applicable to this product.

NCBI GI #
47087085
NCBI GeneID
287702
NCBI Accession #
NP_997710.1
UniProt Primary Accession #
Q6IFU8
UniProt Related Accession #
Q6IFU8
GenBank Nucleotide #
NM_212545.2
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
Krt17
NCBI Official Synonym Symbols
Ka17
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
Cytokeratin-17; CK-17; Keratin-17; K17; Type I keratin Ka17
Protein Family
Keratin
UniProt Gene Name
Krt17
UniProt Synonym Gene Names
CK-17; K17
NCBI Protein Information
keratin, type I cytoskeletal 17

UniProt Comments for Krt17

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Krt17 recombinant protein

 Reference Product  PubMed Publications
 Krt14 recombinant protein  >5 publications with Krt17 and Krt14
 Vim recombinant protein  >2 publications with Krt17 and Vim

Pathways associated with Krt17 recombinant protein

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram

Diseases associated with Krt17 recombinant protein

 Disease Name  Pubmed Publications
 Pachyonychia Congenita Antibodies  >24 publications with Krt17 and Pachyonychia Congenita
 Carcinoma, Squamous Cell Antibodies  >9 publications with Krt17 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >7 publications with Krt17 and Adenocarcinoma
 Pain Antibodies  >4 publications with Krt17 and Pain
 Esophageal Squamous Cell Carcinoma Antibodies  >3 publications with Krt17 and Esophageal Squamous Cell Carcinoma
 Cell Transformation, Neoplastic Antibodies  >2 publications with Krt17 and Cell Transformation, Neoplastic
 Steatocystoma Multiplex Antibodies  >2 publications with Krt17 and Steatocystoma Multiplex
 Carcinoma, Basal Cell Antibodies  >2 publications with Krt17 and Carcinoma, Basal Cell
 Uterine Cervical Neoplasms Antibodies  >1 publications with Krt17 and Uterine Cervical Neoplasms
 Inflammation Antibodies  >1 publications with Krt17 and Inflammation

Organs/Tissues associated with Krt17 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >1 publications with Krt17 and Mixed
 Prostate Antibodies  >1 publications with Krt17 and Prostate
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