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Pulmonary Surfactant-Associated Protein A1 (SFTPA1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1347800

MBS1347800 is a recombinant protein targeting SFTPA1. Also known as Recombinant Human Pulmonary surfactant-associated protein A1 (SFTPA1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$310 / 0.02 mg (Mammalian-Cell) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pulmonary surfactant-associated protein A1 (SFTPA1), Recombinant Protein
Full Product Name
Recombinant Human Pulmonary surfactant-associated protein A1 (SFTPA1)
Product Gene Name
SFTPA1 recombinant protein
Product Synonym Gene Name
SFTPA1
Sequence
EVKDVCVGSP GIPGTPGSHG LPGRDGRDGL KGDPGPPGPM GPPGEMPCPP GNDGLPGAPG IPGECGEKGE PGERGPPGLP AHLDEELQAT LHDFRHQILQ TRGALSLQGS IMTVGEKVFS SNGQSITFDA IQEACARAGG RIAVPRNPEE NEAIASFVKK YNTYAYVGLT EGPSPGDFRY SDGTPVNYTN WYRGEPAGRG KEQCVEMYTD GQWNDRNCLY SRLTICEF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
26.2 kDa
Sequence Positions
21-248aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
178500
3D Structure
ModBase 3D Structure for Q8IWL2
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SFTPA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SFTPA1. It may not necessarily be applicable to this product.

NCBI GI #
257467606
NCBI GeneID
653509
NCBI Accession #
NP_001087239.2
UniProt Primary Accession #
Q8IWL2
UniProt Secondary Accession #
P07714; Q14DV4; Q5RIR5; Q5RIR7; A8K3T8; B7ZW50; E3VLD8; E3VLD9; E3VLE0; E3VLE1; G5E9J3
UniProt Related Accession #
Q8IWL2
GenBank Nucleotide #
NM_001093770.2
NCBI Official Full Name
pulmonary surfactant-associated protein A1 isoform 2
NCBI Official Synonym Full Names
surfactant protein A1
NCBI Official Symbol
SFTPA1
NCBI Official Synonym Symbols
SPA; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B
UniProt Protein Name
Pulmonary surfactant-associated protein A1
UniProt Synonym Protein Names
35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4
Protein Family
Pulmonary surfactant-associated protein
UniProt Gene Name
SFTPA1
UniProt Synonym Gene Names
COLEC4; PSAP; SFTP1; SFTPA; SFTPA1B; PSP-A; PSPA; SP-A; SP-A1
NCBI Protein Information
pulmonary surfactant-associated protein A1

NCBI Summary for SFTPA1

This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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UniProt Comments for SFTPA1

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages ().

Research Articles on SFTPA1

1. Data (including data from studies using transgenic/knockout mice) suggest that surfactant protein A1 (SPA1) interferes with EGF binding to EGFR in pulmonary alveoli cell lines; SPA1 directly binds extracellular domain of EGFR; binding of SPA1 to EGFR appears to be different from binding of SPD to EGFR; binding of SPA1 to EGFR does not suppress EGF-induced phosphorylation of EGFR or cell proliferation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SFTPA1 recombinant protein

 Products by Pathway  Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram

Diseases associated with SFTPA1 recombinant protein

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >37 publications with SFTPA1 and Lung Diseases
 Respiratory Tract Diseases Antibodies  >37 publications with SFTPA1 and Respiratory Tract Diseases
 Inflammation Antibodies  >16 publications with SFTPA1 and Inflammation
 Respiration Disorders Antibodies  >10 publications with SFTPA1 and Respiration Disorders
 Fibrosis Antibodies  >9 publications with SFTPA1 and Fibrosis
 Pulmonary Fibrosis Antibodies  >9 publications with SFTPA1 and Pulmonary Fibrosis
 Lung Neoplasms Antibodies  >8 publications with SFTPA1 and Lung Neoplasms
 Lung Injury Antibodies  >6 publications with SFTPA1 and Lung Injury
 Death Antibodies  >5 publications with SFTPA1 and Death
 Necrosis Antibodies  >5 publications with SFTPA1 and Necrosis

Organs/Tissues associated with SFTPA1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >84 publications with SFTPA1 and Lung
 Blood Antibodies  >11 publications with SFTPA1 and Blood
 Lymph Node Antibodies  >1 publications with SFTPA1 and Lymph Node
 Kidney Antibodies  >1 publications with SFTPA1 and Kidney
 Connective Tissue Antibodies  >1 publications with SFTPA1 and Connective Tissue
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