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Tribbles Homolog 2 (TRIB2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1347918

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins… More details

$1060 / 0.02 mg (E-Coli) +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Tribbles homolog 2 (TRIB2), Recombinant Protein
Full Product Name
Recombinant Human Tribbles homolog 2 (TRIB2)
Product Gene Name
TRIB2 recombinant protein
Product Synonym Gene Name
TRIB2
Sequence
MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
38,801 Da
Sequence Positions
1-343, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
609462
3D Structure
ModBase 3D Structure for Q92519
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TRIB2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIB2 purchase

MBS1347918 is a recombinant protein targeting TRIB2. Also known as Recombinant Human Tribbles homolog 2 (TRIB2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIB2. It may not necessarily be applicable to this product.

NCBI GI #
11056054
NCBI GeneID
28951
NCBI Accession #
NP_067675.1
UniProt Primary Accession #
Q92519
UniProt Secondary Accession #
B2R851; D6W510
UniProt Related Accession #
Q92519
GenBank Nucleotide #
NM_021643.3
NCBI Official Full Name
tribbles homolog 2
NCBI Official Synonym Full Names
tribbles pseudokinase 2
NCBI Official Symbol
TRIB2
NCBI Official Synonym Symbols
C5FW; TRB2; GS3955
UniProt Protein Name
Tribbles homolog 2
Protein Family
Tribbles
UniProt Gene Name
TRIB2
UniProt Synonym Gene Names
TRB-2
NCBI Protein Information
tribbles homolog 2

NCBI Summary for TRIB2

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
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UniProt Comments for TRIB2

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity ().

Research Articles on TRIB2

1. O-GlcNAcylation of TRIB2 might be critical for diabetes-associated liver cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TRIB2 recombinant protein

 Reference Product  PubMed Publications
 SMURF1 recombinant protein  >3 publications with TRIB2 and SMURF1

Diseases associated with TRIB2 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with TRIB2 and Nervous System Diseases
 Carcinoma Antibodies  >8 publications with TRIB2 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >7 publications with TRIB2 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >4 publications with TRIB2 and Disease Models, Animal
 Lung Diseases Antibodies  >4 publications with TRIB2 and Lung Diseases
 Liver Neoplasms Antibodies  >4 publications with TRIB2 and Liver Neoplasms
 Adenocarcinoma Antibodies  >4 publications with TRIB2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >4 publications with TRIB2 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with TRIB2 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >3 publications with TRIB2 and Inflammation

Organs/Tissues associated with TRIB2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with TRIB2 and Blood
 Bone Antibodies  >8 publications with TRIB2 and Bone
 Lung Antibodies  >7 publications with TRIB2 and Lung
 Liver Antibodies  >6 publications with TRIB2 and Liver
 Brain Antibodies  >6 publications with TRIB2 and Brain
 Muscle Antibodies  >4 publications with TRIB2 and Muscle
 Heart Antibodies  >4 publications with TRIB2 and Heart
 Skin Antibodies  >4 publications with TRIB2 and Skin
 Eye Antibodies  >3 publications with TRIB2 and Eye
 Prostate Antibodies  >3 publications with TRIB2 and Prostate
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