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Riboflavin Kinase (RFK) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1349244

MBS1349244 is a recombinant protein targeting RFK. Also known as Recombinant Human Riboflavin kinase (RFK). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$810 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Riboflavin kinase (RFK), Recombinant Protein
Full Product Name
Recombinant Human Riboflavin kinase (RFK)
Product Gene Name
RFK recombinant protein
Product Synonym Gene Name
RFK
Sequence
MRHLPYFCRG QVVRGFGRGS KQLGIPTANF PEQVVDNLPA DISTGIYYGW ASVGSGDVHK MVVSIGWNPY YKNTKKSMET HIMHTFKEDF YGEILNVAIV GYLRPEKNFD SLESLISAIQ GDIEEAKKRL ELPEHLKIKE DNFFQVSKSK IMNGH
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
17,623 Da
Sequence Positions
1-155, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
613010
3D Structure
ModBase 3D Structure for Q969G6
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RFK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RFK. It may not necessarily be applicable to this product.

NCBI GI #
269973877
NCBI GeneID
55312
NCBI Accession #
NP_060809.3
UniProt Primary Accession #
Q969G6
UniProt Secondary Accession #
Q5JSG9; Q9NUT7
UniProt Related Accession #
Q969G6
GenBank Nucleotide #
NM_018339.5
NCBI Official Full Name
riboflavin kinase
NCBI Official Synonym Full Names
riboflavin kinase
NCBI Official Symbol
RFK
NCBI Official Synonym Symbols
RIFK
UniProt Protein Name
Riboflavin kinase
UniProt Synonym Protein Names
ATP:riboflavin 5'-phosphotransferase; Flavokinase
UniProt Gene Name
RFK
NCBI Protein Information
riboflavin kinase

NCBI Summary for RFK

Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]
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UniProt Comments for RFK

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
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Research Articles on RFK

1. DR4 and DR5 have a capability to activate Nox1 by recruiting RFK, resulting in ROS-mediated apoptotic cell death in tumor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RFK recombinant protein

 Reference Product  PubMed Publications
 CYBA recombinant protein  >1 publications with RFK and CYBA
 FLAD1 recombinant protein  >1 publications with RFK and FLAD1

Pathways associated with RFK recombinant protein

 Products by Pathway  Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
 Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies  Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram

Diseases associated with RFK recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with RFK and Disease Models, Animal
 Necrosis Antibodies  >3 publications with RFK and Necrosis
 Inflammation Antibodies  >2 publications with RFK and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with RFK and Cardiovascular Diseases
 Genital Diseases, Male Antibodies  >1 publications with RFK and Genital Diseases, Male
 Hypertension Antibodies  >1 publications with RFK and Hypertension
 Fibrosis Antibodies  >1 publications with RFK and Fibrosis
 Prostatic Neoplasms Antibodies  >1 publications with RFK and Prostatic Neoplasms

Organs/Tissues associated with RFK recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with RFK and Blood
 Bone Antibodies  >4 publications with RFK and Bone
 Vascular Antibodies  >4 publications with RFK and Vascular
 Brain Antibodies  >2 publications with RFK and Brain
 Prostate Antibodies  >1 publications with RFK and Prostate
 Lung Antibodies  >1 publications with RFK and Lung
 Skin Antibodies  >1 publications with RFK and Skin
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