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Plakophilin-1 (PKP1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1350806

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the… More details

$1610 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Plakophilin-1 (PKP1), Recombinant Protein
Full Product Name
Recombinant Human Plakophilin-1 (PKP1)
Product Gene Name
PKP1 recombinant protein
Product Synonym Gene Name
PKP1
Sequence
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS TLSHSNRGSM YDGLADNYNY GTTSRSSYYS KFQAGNGSWG YPIYNGTLKR EPDNRRFSSY SQMENWSRHY PRGSCNTTGA GSDICFMQKI KASRSEPDLY CDPRGTLRKG TLGSKGQKTT QNRYSFYSTC SGQKAIKKCP VRPPSCASKQ DPVYIPPISC NKDLSFGHSR ASSKICSEDI ECSGLTIPKA VQYLSSQDEK YQAIGAYYIQ HTCFQDESAK QQVYQLGGIC KLVDLLRSPN QNVQQAAAGA LRNLVFRSTT NKLETRRQNG IREAVSLLRR TGNAEIQKQL TGLLWNLSST DELKEELIAD ALPVLADRVI IPFSGWCDGN SNMSREVVDP EVFFNATGCL RKRLGMRELL ALVPQRATSS RVNLSSADAG RQTMRNYSGL IDSLMAYVQN CVAASRCDDK SVENCMCVLH NLSYRLDAEV PTRYRQLEYN ARNAYTEKSS TGCFSNKSDK MMNNNYDCPL PEEETNPKGS GWLYHSDAIR TYLNLMGKSK KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPQI ARLLQSGNSD VVRSGASLLS NMSRHPLLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS ACYTVRNLMA SQPQLAKQYF SSSMLNNIIN LCRSSASPKA AEAARLLLSD MWSSKELQGV LRQQGFDRNM LGTLAGANSL RNFTSRF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
80,497 Da
Sequence Positions
1-747, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601975
3D Structure
ModBase 3D Structure for Q13835
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PKP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PKP1 purchase

MBS1350806 is a recombinant protein targeting PKP1. Also known as Recombinant Human Plakophilin-1 (PKP1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for PKP1. It may not necessarily be applicable to this product.

NCBI GI #
53729346
NCBI GeneID
5317
NCBI Accession #
NP_000290.2
UniProt Primary Accession #
Q13835
UniProt Secondary Accession #
O00645; Q14CA0; Q15152
UniProt Related Accession #
Q13835
GenBank Nucleotide #
NM_000299.3
NCBI Official Full Name
plakophilin-1 isoform 1b
NCBI Official Synonym Full Names
plakophilin 1
NCBI Official Symbol
PKP1
NCBI Official Synonym Symbols
B6P
UniProt Protein Name
Plakophilin-1
UniProt Synonym Protein Names
Band 6 protein; B6P
Protein Family
Plakophilin
UniProt Gene Name
PKP1
UniProt Synonym Gene Names
B6P
NCBI Protein Information
plakophilin-1

NCBI Summary for PKP1

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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UniProt Comments for PKP1

Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.

Research Articles on PKP1

1. These results implicate the participation of PKP1 in early tooth morphogenesis as an effector of canonical Wnt signaling that controls ameloblast differentiation via regulation of the cell adhesion complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PKP1 recombinant protein

 Reference Product  PubMed Publications
 DSP recombinant protein  >7 publications with PKP1 and DSP
 DSG1 recombinant protein  >6 publications with PKP1 and DSG1
 DSG3 recombinant protein  >4 publications with PKP1 and DSG3
 DSC1 recombinant protein  >2 publications with PKP1 and DSC1
 EIF4A1 recombinant protein  >1 publications with PKP1 and EIF4A1

Pathways associated with PKP1 recombinant protein

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram

Diseases associated with PKP1 recombinant protein

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >18 publications with PKP1 and Congenital Abnormalities
 Neoplasms Antibodies  >16 publications with PKP1 and Neoplasms
 Ectodermal dysplasia/ skin fragility syndrome Antibodies  >8 publications with PKP1 and Ectodermal dysplasia/ skin fragility syndrome
 Respiratory Tract Diseases Antibodies  >2 publications with PKP1 and Respiratory Tract Diseases
 Neoplasms, Experimental Antibodies  >1 publications with PKP1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >1 publications with PKP1 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >1 publications with PKP1 and Liver Diseases
 Inflammation Antibodies  >1 publications with PKP1 and Inflammation
 Precancerous Conditions Antibodies  >1 publications with PKP1 and Precancerous Conditions
 Hyperplasia Antibodies  >1 publications with PKP1 and Hyperplasia

Organs/Tissues associated with PKP1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >29 publications with PKP1 and Skin
 Heart Antibodies  >6 publications with PKP1 and Heart
 Lung Antibodies  >4 publications with PKP1 and Lung
 Esophagus Antibodies  >3 publications with PKP1 and Esophagus
 Prostate Antibodies  >3 publications with PKP1 and Prostate
 Liver Antibodies  >1 publications with PKP1 and Liver
 Intestine Antibodies  >1 publications with PKP1 and Intestine
 Bladder Antibodies  >1 publications with PKP1 and Bladder
 Muscle Antibodies  >1 publications with PKP1 and Muscle
 Stomach Antibodies  >1 publications with PKP1 and Stomach
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