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Sheep Anti-Human Protein Z (PROZ) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135211

Polyclonal antibody (host sheep). IgG fraction purified by immobilized Protein G. More details

$490 / 1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sheep anti-Human Protein Z (PROZ), Polyclonal Antibody
Full Product Name
Sheep anti-Human Protein Z
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Host: Sheep; Source: Sheep serum
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
IgG fraction
Concentration
5.0 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Shelf Life: 12 months from delivery
Molecular Weight
160,000
Chromosome Location
Chromosome: 13; NC_000013.10 (113812968..113826698). Location: 13q34
OMIM
176895
3D Structure
ModBase 3D Structure for P22891
Immunogen
Full length native protein (purified) (Human).
Target Information
Recognises Protein Z
Target Molecular Weight
62000
Buffer
50% Glycerol
Extinction Coefficient
1.36
Applications Tested/Suitable for anti-PROZ antibody
ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-PROZ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PROZ purchase

MBS135211 is an antibody targeting PROZ. Also known as Sheep anti-Human Protein Z. Reactive in Human. Host: Sheep; Source: Sheep serum.

Additional Details

NCBI/Uniprot data below describe general gene information for PROZ. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
vitamin K-dependent protein Z isoform 1
NCBI Official Synonym Full Names
protein Z, vitamin K-dependent plasma glycoprotein
NCBI Official Symbol
PROZ
NCBI Official Synonym Symbols
PZ
UniProt Protein Name
Vitamin K-dependent protein Z
UniProt Gene Name
PROZ
UniProt Entry Name
PROZ_HUMAN
NCBI Protein Information
vitamin K-dependent protein Z

NCBI Summary for PROZ

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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UniProt Comments for PROZ

PROZ: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: Golgi lumen; endoplasmic reticulum lumen

Molecular Function: serine-type endopeptidase activity; calcium ion binding

Biological Process: cellular protein metabolic process; blood coagulation; post-translational protein modification; proteolysis; peptidyl-glutamic acid carboxylation

Disease: Protein Z Deficiency
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-PROZ antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with PROZ and Liver
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