Mouse GNE Recombinant Protein – Cat# MBS1352636

Bifunctional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase (GNE) Mouse Recombinant Protein

Name: GNE Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1352636
Price: 1580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1352636

This protein is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface… More details

$1580 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne), Recombinant Protein

Full Product Name

Recombinant Mouse Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne)

Product Gene Name

Gne recombinant protein

Product Synonym Gene Name

Gne

Sequence

MEKNGNNRKL RVCVATCNRA DYSKLAPIMF GIKTEPAFFE LDVVVLGSHL IDDYGNTYRM IEQDDFDINT RLHTIVRGED EAAMVESVGL ALVKLPDVLN RLKPDIMIVH GDRFDALALA TSAALMNIRI LHIEGGEVSG TIDDSIRHAI TKLAHYHVCC TRSAEQHLIS MCEDHDRILL AGCPSYDKLL SAKNKDYMSI IRMWLGDDVK CKDYIVALQH PVTTDIKHSI KMFELTLDAL ISFNKRTLVL FPNIDAGSKE MVRVMRKKGI EHHPNFRAVK HVPFDQFIQL VAHAGCMIGN SSCGVREVGA FGTPVINLGT RQIGRETGEN VLHVRDADTQ DKILQALHLQ FGKQYPCSKI YGDGNAVPRI LKFLKSIDLQ EPLQKKFCFP PVKENISQDI DHILETLSAL AVDLGGTNLR VAIVSMKGEI VKKYTQFNPK TYEERISLIL QMCVEAAAEA VKLNCRILGV GISTGGRVNP QEGVVLHSTK LIQEWNSVDL RTPLSDTLHL PVWVDNDGNC AAMAERKFGQ GKGQENFVTL ITGTGIGGGI IHQHELIHGS SFCAAELGHL VVSLDGPDCS CGSHGCIEAY ASGMALQREA KKLHDEDLLL VEGMSVPKDE AVGALHLIQA AKLGNVKAQS ILRTAGTALG LGVVNILHTM NPSLVILSGV LASHYIHIVK DVIRQQALSS VQDVDVVVSD LVDPALLGAA SMVLDYTTRR IH

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

79,199 Da

Sequence Positions

1-722, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q91WG8

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Gne recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gne purchase

MBS1352636 is a recombinant protein targeting Gne. Also known as Recombinant Mouse Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Gne. It may not necessarily be applicable to this product.

NCBI GI #

298676517

NCBI GeneID

50798

NCBI Accession #

NP_001177343.1

UniProt Primary Accession #

Q91WG8

UniProt Secondary Accession #

Q8CC83; Q8CCB0; Q9Z0P6

UniProt Related Accession #

Q91WG8

GenBank Nucleotide #

NM_001190414.2

NCBI Official Full Name

bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1

NCBI Official Synonym Full Names

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

NCBI Official Symbol

Gne

NCBI Official Synonym Symbols

NM; DMRV; IBM2; Uae1; GLCNE; 2310066H07Rik

UniProt Protein Name

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

UniProt Synonym Protein Names

UDP-GlcNAc-2-epimerase/ManAc kinaseIncluding the following 2 domains:UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC:3.2.1.183)Alternative name(s):UDP-GlcNAc-2-epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimerase

Protein Family

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

UniProt Gene Name

Gne

UniProt Synonym Gene Names

Glcne; Uae1

NCBI Protein Information

bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

UniProt Comments for Gne

Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells (). Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development.

Research Articles on Gne

1. GNE is a master regulator of sialic acid synthesis in the vertebrates. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Gne recombinant protein

Products by Pathway	Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
CMP-N-acetylneuraminate Biosynthesis I (eukaryotes) Pathway antibodies	CMP-N-acetylneuraminate Biosynthesis I (eukaryotes) Pathway Diagram
N-acetylneuraminate And N-acetylmannosamine Degradation Pathway antibodies	N-acetylneuraminate And N-acetylmannosamine Degradation Pathway Diagram
Superpathway Of N-acetylglucosamine, N-acetylmannosamine And N-acetylneuraminate Degradation antibodies	Superpathway Of N-acetylglucosamine, N-acetylmannosamine And N-acetylneuraminate Degradation Diagram

Diseases associated with Gne recombinant protein

Disease Name	Pubmed Publications
Muscular Diseases Antibodies	>83 publications with Gne and Muscular Diseases
Myositis, Inclusion Body Antibodies	>44 publications with Gne and Myositis, Inclusion Body
Neurologic Manifestations Antibodies	>13 publications with Gne and Neurologic Manifestations
Brain Diseases Antibodies	>7 publications with Gne and Brain Diseases
Neoplasms Antibodies	>7 publications with Gne and Neoplasms
Inflammation Antibodies	>5 publications with Gne and Inflammation
Sialic Acid Storage Disease Antibodies	>5 publications with Gne and Sialic Acid Storage Disease
Proteinuria Antibodies	>4 publications with Gne and Proteinuria
Drug Toxicity Antibodies	>4 publications with Gne and Drug Toxicity
Cardiovascular Diseases Antibodies	>3 publications with Gne and Cardiovascular Diseases

Organs/Tissues associated with Gne recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>13 publications with Gne and Brain
Embryonic Tissue Antibodies	>8 publications with Gne and Embryonic Tissue
Kidney Antibodies	>7 publications with Gne and Kidney
Liver Antibodies	>5 publications with Gne and Liver
Lung Antibodies	>4 publications with Gne and Lung
Connective Tissue Antibodies	>3 publications with Gne and Connective Tissue
Testis Antibodies	>2 publications with Gne and Testis
Eye Antibodies	>1 publications with Gne and Eye
Uncharacterized Tissue Antibodies	>1 publications with Gne and Uncharacterized Tissue
Prostate Antibodies	>1 publications with Gne and Prostate