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Biotin Labeled Affinity Purified Sheep Anti Mouse Neuroserpin (SERPINI1) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135269

Biotin labeled affinity purified polyclonal antibody (host sheep) to mouse neuroserpin (His Tag). Affinity purified by immobilized mouse neuroserpin followed by biotin conjugation. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Biotin labeled affinity purified sheep anti mouse neuroserpin (SERPINI1), Polyclonal Antibody
Full Product Name
Biotin labeled affinity purified sheep anti mouse neuroserpin
Product Gene Name
anti-SERPINI1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Host: Sheep; Source: Sheep serum
Species Reactivity
Mouse
Form/Format
Frozen liquid
Purity/Purification
Affinity purification
Concentration
1.0 mg/ml (lot specific)
Preparation and Storage
Store at -70 degree C. Shelf Life: 5 years from delivery
Molecular Weight
160,000
Chromosome Location
Chromosome: 3; NC_000069.6 (75557533..75642523). Location: 3 E3; 3
3D Structure
ModBase 3D Structure for O35684
Immunogen
Recombinant full length mouse protein fused to a His tag at N-terminal end (Glycosylated).
Target Information
Recognises Neuroserpin
Target Molecular Weight
49000
Buffer
0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
Extinction Coefficient
1.36

Product Categories/Family for anti-SERPINI1 antibody

Neuroserpin; Polyclonal Antibodies to Mouse Neuroserpin
Applications Tested/Suitable for anti-SERPINI1 antibody
ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-SERPINI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINI1 purchase

MBS135269 is an antibody targeting SERPINI1. Also known as Biotin labeled affinity purified sheep anti mouse neuroserpin. Reactive in Mouse. Host: Sheep; Source: Sheep serum.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINI1. It may not necessarily be applicable to this product.

NCBI GI #
6678091
NCBI GeneID
20713
NCBI Accession #
NP_033276.1
UniProt Primary Accession #
O35684
UniProt Secondary Accession #
Q543F7; Q922U6
UniProt Related Accession #
O35684
GenBank Nucleotide #
NM_009250.2
NCBI Official Full Name
neuroserpin
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade I, member 1
NCBI Official Symbol
Serpini1
NCBI Official Synonym Symbols
Ns; PI12; PI-12; Spi17; AI837402
UniProt Protein Name
Neuroserpin
UniProt Synonym Protein Names
Peptidase inhibitor 12; PI-12; Serine protease inhibitor 17; Serpin I1
Protein Family
Neuroserpin
UniProt Gene Name
Serpini1
UniProt Synonym Gene Names
Pi12; Spi17; PI-12
UniProt Entry Name
NEUS_MOUSE
NCBI Protein Information
neuroserpin; serpin I1; protease inhibitor 17; peptidase inhibitor 12; serine protease inhibitor 17

UniProt Comments for SERPINI1

SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protease inhibitor activity

Biological Process: regulation of cell adhesion; negative regulation of peptidase activity
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Research Articles on SERPINI1

1. Data indicate that the neuroprotective effect of neuroserpin is due to inhibition of plasmin-mediated excitotoxin-induced cell death and is independent of neuroserpin's ability to inhibit tissue plasminogen activator activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SERPINI1 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >3 publications with SERPINI1 and Mental Disorders
 Liver Diseases Antibodies  >1 publications with SERPINI1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >1 publications with SERPINI1 and Cardiovascular Diseases
 Schizophrenia Antibodies  >1 publications with SERPINI1 and Schizophrenia
 Familial encephalopathy with neuroserpin inclusion bodies Antibodies  >1 publications with SERPINI1 and Familial encephalopathy with neuroserpin inclusion bodies

Organs/Tissues associated with anti-SERPINI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with SERPINI1 and Brain
 Embryonic Tissue Antibodies  >1 publications with SERPINI1 and Embryonic Tissue
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