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Partitioning Defective 6 Homolog Alpha (PARD6A) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1353297

This gene is a member of the PAR6 family and encodes a protein with a PSD95Discs-largeZO1 (PDZ) domain and a semi-Cdc42Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes… More details

$1060 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Partitioning defective 6 homolog alpha (Pard6a), Recombinant Protein
Full Product Name
Recombinant Rat Partitioning defective 6 homolog alpha (Pard6a)
Product Gene Name
Pard6a recombinant protein
Product Synonym Gene Name
Pard6a
Sequence
MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRTSVRGFQ EFSRLLCVVH QIPGLDVLLG YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEGDS SGLAFASNSL QRRKKGLLLR PVAPLRTRPP LLISLPQDFR QVSSVIDVDL LPETHRRVRL HKHGSDRPLG FYIRDGMSVR VAPQGLERVP GIFISRLVRG GLAESTGLLA VSDEILEVNG IEVAGKTLDQ VTDMMVANSH NLIVTVKPAN QRNNVVRGAS GRLTGPSSVG PGPTDPDSDD DNSDPVIENR HPPCSNGLSQ GPLCWDLQPG CLHPSAGSSL PSLDSREQAN SGWGNGMRGD VSGFSL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
17,679 Da
Sequence Positions
1-346, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6B4M5
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Pard6a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pard6a purchase

MBS1353297 is a recombinant protein targeting Pard6a. Also known as Recombinant Rat Partitioning defective 6 homolog alpha (Pard6a). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Pard6a. It may not necessarily be applicable to this product.

NCBI GI #
76363287
NCBI GeneID
307799
NCBI Accession #
Q6B4M5.2
UniProt Primary Accession #
Q6B4M5
UniProt Secondary Accession #
Q4U4X0; Q6B4M6
UniProt Related Accession #
Q6B4M5
NCBI Official Full Name
Partitioning defective 6 homolog alpha
NCBI Official Synonym Full Names
par-6 family cell polarity regulator alpha
NCBI Official Symbol
Pard6a
NCBI Official Synonym Symbols
Par6a; Par-6a
UniProt Protein Name
Partitioning defective 6 homolog alpha
Protein Family
Partitioning defective
UniProt Gene Name
Pard6a
UniProt Synonym Gene Names
Par-6a; Par6a; PAR-6; PAR-6 alpha; PAR-6A
NCBI Protein Information
partitioning defective 6 homolog alpha

NCBI Summary for Pard6a

The protein encoded by this gene is a component of the partitioning defective complex, a protein complex involved in controlling epithelial cell polarity as well as other cell processes. In rat testis cells, the protein localizes to the apical ectoplasmic specialization at the Sertoli-elongating spermatid interface and at the blood-testis barrier. Accordingly, knockdown of this gene in Sertoli cell epithelia results in compromised blood-testis barrier integrity. Knockdown of this gene in various neuronal cell types results in a variety of phenotypes including abnormal dendritic spine morphogenesis and defective axon outgrowth to the spinal midline. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
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UniProt Comments for Pard6a

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization.
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Research Articles on Pard6a

1. Altogether, our studies proved that inhibition of let-7f-5p facilitates induction of MSCs into neuron-like cells by directly targeting Par6alpha.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Pard6a recombinant protein

 Reference Product  PubMed Publications
 Cdc42 recombinant protein  >14 publications with Pard6a and Cdc42
 Rac1 recombinant protein  >5 publications with Pard6a and Rac1
 Prkcz recombinant protein  >2 publications with Pard6a and Prkcz

Pathways associated with Pard6a recombinant protein

 Products by Pathway  Pathway Diagram
 Asymmetric Localization Of PCP Proteins Pathway antibodies  Asymmetric Localization Of PCP Proteins Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 PCP/CE Pathway antibodies  PCP/CE Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram

Diseases associated with Pard6a recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >11 publications with Pard6a and Carcinoma
 Lung Neoplasms Antibodies  >7 publications with Pard6a and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >4 publications with Pard6a and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >4 publications with Pard6a and Breast Neoplasms
 Inflammation Antibodies  >2 publications with Pard6a and Inflammation
 Necrosis Antibodies  >2 publications with Pard6a and Necrosis
 Neoplasm Metastasis Antibodies  >1 publications with Pard6a and Neoplasm Metastasis
 Liver Diseases Antibodies  >1 publications with Pard6a and Liver Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with Pard6a and Urinary Bladder Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with Pard6a and Carcinoma, Hepatocellular
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