Antiplasmin Antiserum (SERPINF2) Antibody – Rabbit Polyclonal

SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein homodimerization activity; protease binding; protease inhibitor activity

Biological Process: collagen fibril organization; negative regulation of fibrinolysis; renin-angiotensin regulation of blood vessel size; positive regulation of smooth muscle cell proliferation; positive regulation of stress fiber formation; positive regulation of collagen biosynthetic process; acute-phase response; positive regulation of JNK cascade; blood vessel morphogenesis; negative regulation of peptidase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation

Disease: Alpha-2-plasmin Inhibitor Deficiency