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Bardet-Biedl Syndrome 1 Protein (BBS1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1354426

Mutations in this gene have been observed in patients with the major form (type 1) of Bardet-Biedl syndrome. The encoded protein may play a role in eye, limb, cardiac and reproductive system development. More details

$1385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Bardet-Biedl syndrome 1 protein (BBS1), Recombinant Protein
Full Product Name
Recombinant Human Bardet-Biedl syndrome 1 protein (BBS1)
Product Gene Name
BBS1 recombinant protein
Product Synonym Gene Name
BBS1
Sequence
AAASSSDSDA CGAESNEANS KWLDAHYDPM ANIHTFSACL ALADLHGDGE YKLVVGDLGP GGQQPRLKVL KGPLVMTESP LPALPAAAAT FLMEQHEPRT PALALASGPC VYVYKNLRPY FKFSLPQLPP NPLEQDLWNQ AKEDRIDPLT LKEMLESIRE TAEEPLSIQS LRFLQLELSE MEAFVNQHKS NSIKRQTVIT TMTTLKKNLA DEDAVSCLVL GTENKELLVL DPEAFTILAK MSLPSVPVFL EVSGQFDVEF RLAAACRNGN IYILRRDSKH PKYCIELSAQ PVGLIRVHKV LVVGSTQDSL HGFTHKGKKL WTVQMPAAIL TMNLLEQHSR GLQAVMAGLA NGEVRIYRDK ALLNVIHTPD AVTSLCFGRY GREDNTLIMT TRGGGLIIKI LKRTAVFVEG GSEVGPPPAQ AMKLNVPRKT RLYVDQTLRE REAGTAMHRA FQTDLYLLRL RAARAYLQAL ESSLSPLSTT AREPLKLHAV VQGLGPTFKL TLHLQNTSTT RPVLGLLVCF LYNEALYSLP RAFFKVPLLV PGLNYPLETF VESLSNKGIS DIIKVLVLRE GQSAPLLSAH VNMPGSEGLA AA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
49,006 Da
Sequence Positions
2-593aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
209900
3D Structure
ModBase 3D Structure for Q8NFJ9
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of BBS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BBS1 purchase

MBS1354426 is a recombinant protein targeting BBS1. Also known as Recombinant Human Bardet-Biedl syndrome 1 protein (BBS1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for BBS1. It may not necessarily be applicable to this product.

NCBI GI #
28395045
NCBI GeneID
582
NCBI Accession #
NP_078925.3
UniProt Primary Accession #
Q8NFJ9
UniProt Secondary Accession #
Q32MM9; Q32MN0; Q96SN4
UniProt Related Accession #
Q8NFJ9
GenBank Nucleotide #
NM_024649.4
NCBI Official Full Name
Bardet-Biedl syndrome 1 protein
NCBI Official Synonym Full Names
Bardet-Biedl syndrome 1
NCBI Official Symbol
BBS1
NCBI Official Synonym Symbols
BBS2L2
UniProt Protein Name
Bardet-Biedl syndrome 1 protein
UniProt Synonym Protein Names
BBS2-like protein 2
Protein Family
Bardet-Biedl syndrome 1 protein
UniProt Gene Name
BBS1
UniProt Synonym Gene Names
BBS2L2
NCBI Protein Information
Bardet-Biedl syndrome 1 protein

UniProt Comments for BBS1

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking ().
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Research Articles on BBS1

1. Importantly, one Japanese and one Omani families carried compound biallelic mutations in two distinct genes (TMEM67/RPGRIP1L and TMEM138/BBS1, respectively).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BBS1 recombinant protein

 Reference Product  PubMed Publications
 BBS2 recombinant protein  >49 publications with BBS1 and BBS2
 BBS4 recombinant protein  >47 publications with BBS1 and BBS4
 BBS7 recombinant protein  >20 publications with BBS1 and BBS7
 BBS12 recombinant protein  >17 publications with BBS1 and BBS12
 BBS5 recombinant protein  >17 publications with BBS1 and BBS5
 BBS9 recombinant protein  >6 publications with BBS1 and BBS9
 ARL6 recombinant protein  >5 publications with BBS1 and ARL6
 TTC8 recombinant protein  >4 publications with BBS1 and TTC8

Diseases associated with BBS1 recombinant protein

 Disease Name  Pubmed Publications
 Bardet-Biedl Syndrome Antibodies  >108 publications with BBS1 and Bardet-Biedl Syndrome
 Heart Defects, Congenital Antibodies  >6 publications with BBS1 and Heart Defects, Congenital
 Death Antibodies  >3 publications with BBS1 and Death
 Infertility, Male Antibodies  >3 publications with BBS1 and Infertility, Male
 Gonadal Disorders Antibodies  >3 publications with BBS1 and Gonadal Disorders
 Disease Progression Antibodies  >3 publications with BBS1 and Disease Progression
 Weight Gain Antibodies  >2 publications with BBS1 and Weight Gain
 Weight Loss Antibodies  >2 publications with BBS1 and Weight Loss
 Inflammation Antibodies  >2 publications with BBS1 and Inflammation
 Cognition Disorders Antibodies  >1 publications with BBS1 and Cognition Disorders

Organs/Tissues associated with BBS1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >24 publications with BBS1 and Kidney
 Eye Antibodies  >24 publications with BBS1 and Eye
 Heart Antibodies  >14 publications with BBS1 and Heart
 Blood Antibodies  >6 publications with BBS1 and Blood
 Brain Antibodies  >6 publications with BBS1 and Brain
 Liver Antibodies  >5 publications with BBS1 and Liver
 Stomach Antibodies  >4 publications with BBS1 and Stomach
 Skin Antibodies  >2 publications with BBS1 and Skin
 Embryonic Tissue Antibodies  >2 publications with BBS1 and Embryonic Tissue
 Adipose Tissue Antibodies  >2 publications with BBS1 and Adipose Tissue
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