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Oxysterol-Binding Protein-Related Protein 8 (OSBPL8) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1356355

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like… More details

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Product Overview

Online Datasheet in PDF
Product Name
Oxysterol-binding protein-related protein 8 (OSBPL8), Recombinant Protein
Full Product Name
Recombinant Human Oxysterol-binding protein-related protein 8 (OSBPL8) , partial
Product Gene Name
OSBPL8 recombinant protein
Product Synonym Gene Name
OSBPL8
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
96,956 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606736
3D Structure
ModBase 3D Structure for Q9BZF1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of OSBPL8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OSBPL8 purchase

MBS1356355 is a recombinant protein targeting OSBPL8. Also known as Recombinant Human Oxysterol-binding protein-related protein 8 (OSBPL8) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for OSBPL8. It may not necessarily be applicable to this product.

NCBI GI #
51243032
NCBI GeneID
114882
NCBI Accession #
NP_001003712.1
UniProt Primary Accession #
Q9BZF1
UniProt Secondary Accession #
Q52LQ3; Q68D75; Q8WXP8; Q9P277; A8K1T2; E9PE66; E9PE68
UniProt Related Accession #
Q9BZF1
GenBank Nucleotide #
NM_001003712.1
NCBI Official Full Name
oxysterol-binding protein-related protein 8 isoform b
NCBI Official Synonym Full Names
oxysterol binding protein like 8
NCBI Official Symbol
OSBPL8
NCBI Official Synonym Symbols
ORP8; MST120; OSBP10; MSTP120
UniProt Protein Name
Oxysterol-binding protein-related protein 8
Protein Family
Oxysterol-binding protein-related protein
UniProt Gene Name
OSBPL8
UniProt Synonym Gene Names
; ORP-8; OSBP-related protein 8
NCBI Protein Information
oxysterol-binding protein-related protein 8

NCBI Summary for OSBPL8

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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UniProt Comments for OSBPL8

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267).
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Research Articles on OSBPL8

1. ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with OSBPL8 recombinant protein

 Reference Product  PubMed Publications
 ZDHHC17 recombinant protein  >1 publications with OSBPL8 and ZDHHC17
 RUNX2 recombinant protein  >1 publications with OSBPL8 and RUNX2

Organs/Tissues associated with OSBPL8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with OSBPL8 and Blood
 Nerve Antibodies  >1 publications with OSBPL8 and Nerve
 Liver Antibodies  >1 publications with OSBPL8 and Liver
 Heart Antibodies  >1 publications with OSBPL8 and Heart
 Kidney Antibodies  >1 publications with OSBPL8 and Kidney
 Brain Antibodies  >1 publications with OSBPL8 and Brain
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