Human CTSG Active Protein – Cat# MBS135682

Cathepsin G (CTSG) Human Active Protein

Name: CTSG Active Protein; Cathepsin G; Human; MyBioSource
Brand: MyBioSource
SKU: MBS135682
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135682

MBS135682 is an active protein targeting CTSG. Also known as Human Cathepsin G. Host: Human neutrophil. Cathepsin G is a serine protease purified from neutrophils that has More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Cathepsin G (CTSG), Active Protein

Full Product Name

Human Cathepsin G

Product Gene Name

CTSG active protein

Host

Human neutrophil

Form/Format

Frozen liquid

Purity/Purification

>95% by SDS-PAGE analysis

Concentration

1.0 mg/ml (lot specific)

Preparation and Storage

Store at -70 degree C. Shelf Life: 3 years from delivery

Molecular Weight

30,000

Chromosome Location

Chromosome: 14; NC_000014.8 (25042724..25045466, complement). Location: 14q11.2

OMIM

116830

3D Structure

ModBase 3D Structure for P08311

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Specific Activity

8.5 U/mg (One unit will hydrolyze one micromole of Succinyl-alanine-alanine-propline-phenylalanine-p-nitroanilide per minute at 37 C and pH 7.5)

Buffer

0.05M Sodium Acetate; 0.8M NaCl; pH 5.5

Extinction Coefficient

0.66

Product Categories/Family for CTSG active protein

Cathepsin; Human Cathepsins

Other Notes

Small volumes of CTSG active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSG. It may not necessarily be applicable to this product.

NCBI GI #

4503149

NCBI GeneID

1511

NCBI Accession #

NP_001902.1

UniProt Primary Accession #

P08311

UniProt Secondary Accession #

Q6IBJ6; Q9UCA5; Q9UCU6

UniProt Related Accession #

P08311

GenBank Nucleotide #

NM_001911.2

NCBI Official Full Name

cathepsin G preproprotein

NCBI Official Synonym Full Names

cathepsin G

NCBI Official Symbol

CTSG

NCBI Official Synonym Symbols

CG; CATG

UniProt Protein Name

Cathepsin G

Protein Family

Cathepsin

UniProt Gene Name

CTSG

UniProt Synonym Gene Names

UniProt Entry Name

CATG_HUMAN

NCBI Protein Information

cathepsin G

NCBI Summary for CTSG

The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for CTSG

CTSG: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. Belongs to the peptidase S1 family.

Protein type: Protease; EC 3.4.21.20; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular matrix; extracellular space; cell surface; plasma membrane; extracellular region; nucleus; secretory granule

Molecular Function: peptidase activity; heparin binding; serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; positive regulation of immune response; extracellular matrix organization and biogenesis; cellular protein metabolic process; protein processing; immune response; response to lipopolysaccharide; proteolysis; angiotensin maturation; defense response to fungus

Research Articles on CTSG

1. NE and CG bind to the surface of cancer cells, presumably to a cell surface receptor, and subsequently undergo clathrin pit-mediated endocytosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTSG active protein

Reference Product	PubMed Publications
THBS1 active protein	>6 publications with CTSG and THBS1
PPBP active protein	>3 publications with CTSG and PPBP
CXCR4 active protein	>3 publications with CTSG and CXCR4
CXCL12 active protein	>3 publications with CTSG and CXCL12
CAMP active protein	>3 publications with CTSG and CAMP
CASP7 active protein	>3 publications with CTSG and CASP7
SDC1 active protein	>1 publications with CTSG and SDC1
IGFBP3 active protein	>1 publications with CTSG and IGFBP3
SERPINA3 active protein	>1 publications with CTSG and SERPINA3
VCAM1 active protein	>1 publications with CTSG and VCAM1

Pathways associated with CTSG active protein

Products by Pathway	Pathway Diagram
ACE Inhibitor Pathway antibodies	ACE Inhibitor Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies	Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram

Diseases associated with CTSG active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>140 publications with CTSG and Inflammation
Cardiovascular Diseases Antibodies	>44 publications with CTSG and Cardiovascular Diseases
Leukemia Antibodies	>35 publications with CTSG and Leukemia
Necrosis Antibodies	>32 publications with CTSG and Necrosis
Fibrosis Antibodies	>28 publications with CTSG and Fibrosis
Leukemia, Myeloid, Acute Antibodies	>27 publications with CTSG and Leukemia, Myeloid, Acute
Arthritis, Rheumatoid Antibodies	>24 publications with CTSG and Arthritis, Rheumatoid
Colitis Antibodies	>18 publications with CTSG and Colitis
Liver Diseases Antibodies	>10 publications with CTSG and Liver Diseases
Hemorrhage Antibodies	>10 publications with CTSG and Hemorrhage

Organs/Tissues associated with CTSG active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>610 publications with CTSG and Blood
Skin Antibodies	>42 publications with CTSG and Skin
Bone Antibodies	>37 publications with CTSG and Bone
Connective Tissue Antibodies	>32 publications with CTSG and Connective Tissue
Bone Marrow Antibodies	>27 publications with CTSG and Bone Marrow
Liver Antibodies	>19 publications with CTSG and Liver
Kidney Antibodies	>17 publications with CTSG and Kidney
Brain Antibodies	>17 publications with CTSG and Brain
Heart Antibodies	>15 publications with CTSG and Heart
Eye Antibodies	>5 publications with CTSG and Eye