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Dog Renin, C-Terminal 8x His Tag (REN) Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135690

Renin is an aspartyl protease that is specific for only one substrate, angiotensinogen. Our dog renin is produced from the proenzyme prorenin by proteolytic cleavage of a 43 amino acid N-terminal prosegment using limited enzymatic digestion by immobilized More details

$795 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dog Renin, C-terminal 8x His tag, Protein
Full Product Name
Dog Renin, C-terminal 8x His tag
Product Gene Name
Host
Human Embryonic Kidney cells
Form/Format
Frozen liquid
Purity/Purification
>95% by SDS-PAGE analysis
Concentration
1.0 mg/ml (lot specific)
Preparation and Storage
Store at -70 degree C. Shelf Life: 3 years from delivery
Molecular Weight
36,700
Chromosome Location
Chromosome: 38; NC_006620.3 (744730..755012, complement). Location: chromosome: 38
3D Structure
ModBase 3D Structure for Q6DYE7
Buffer
0.05M Tris-HCl; pH 8.0
Extinction Coefficient
1.1

Product Categories/Family for REN protein

Other Notes

Small volumes of REN protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for REN purchase

MBS135690 is a protein targeting REN. Also known as Dog Renin, C-terminal 8x His tag. Host: Human Embryonic Kidney cells.

Additional Details

NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
renin
NCBI Official Symbol
REN
UniProt Protein Name
Renin
UniProt Synonym Protein Names
Angiotensinogenase
Protein Family
UniProt Gene Name
REN
UniProt Entry Name
RENI_CANFA
NCBI Protein Information
renin; angiotensinogenase

UniProt Comments for REN

Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

By similarity.

Catalytic activity: Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

Enzyme regulation: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing

By similarity.

Subunit structure: Interacts with ATP6AP2

By similarity.

Subcellular location: Secreted

By similarity. Membrane

By similarity. Note: Associated to membranes via binding to ATP6AP2

By similarity.

Sequence similarities: Belongs to the peptidase A1 family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with REN protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >749 publications with REN and Kidney
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