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Zinc Finger Protein SNAI2 (SNAI2) Bovine Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1357893

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This… More details

$950 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Zinc finger protein SNAI2 (SNAI2), Recombinant Protein
Full Product Name
Recombinant Bovine Zinc finger protein SNAI2 (SNAI2)
Product Gene Name
SNAI2 recombinant protein
Product Synonym Gene Name
SNAI2
Sequence
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PCLYEGYPVP VIPQPEVLRS GAYSPIAVWT TASPFHAPLP AGLSPLSGYP ASLGRVSPPP PSDTSSKDHS GSESPISDEE ERLQSKLSDP HAIEAEKFQC NLCNKTYSTF SGLGKHKQLH CDAQSRKSFS CKYCDKEYVS LGALKMHIRT HTLPCVCKIC GKAFSRPWLL QGHIRTHTGE KPFSCSHCSR AFADRSNLRA HLQTHSDVKK YQCKSCSKTF SRMSLLHKHE ESGCCAAH
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
29,729 Da
Sequence Positions
1-268, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q3MHQ4
Species
Bovine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SNAI2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNAI2 purchase

MBS1357893 is a recombinant protein targeting SNAI2. Also known as Recombinant Bovine Zinc finger protein SNAI2 (SNAI2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SNAI2. It may not necessarily be applicable to this product.

NCBI GI #
77736023
NCBI GeneID
520631
NCBI Accession #
NP_001029710.1
UniProt Primary Accession #
Q3MHQ4
UniProt Related Accession #
Q3MHQ4
GenBank Nucleotide #
NM_001034538.2
NCBI Official Full Name
zinc finger protein SNAI2
NCBI Official Synonym Full Names
snail family transcriptional repressor 2
NCBI Official Symbol
SNAI2
UniProt Protein Name
Zinc finger protein SNAI2
UniProt Synonym Protein Names
Neural crest transcription factor Slug; Protein snail homolog 2
Protein Family
Zinc finger protein
UniProt Gene Name
SNAI2
UniProt Synonym Gene Names
SLUG
NCBI Protein Information
zinc finger protein SNAI2

UniProt Comments for SNAI2

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SNAI2 recombinant protein

 Reference Product  PubMed Publications
 TWIST1 recombinant protein  >35 publications with SNAI2 and TWIST1
 CDH1 recombinant protein  >24 publications with SNAI2 and CDH1
 SOX10 recombinant protein  >17 publications with SNAI2 and SOX10
 MMP9 recombinant protein  >10 publications with SNAI2 and MMP9
 TP53 recombinant protein  >3 publications with SNAI2 and TP53
 SMAD4 recombinant protein  >2 publications with SNAI2 and SMAD4
 LEF1 recombinant protein  >1 publications with SNAI2 and LEF1

Pathways associated with SNAI2 recombinant protein

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram

Diseases associated with SNAI2 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >35 publications with SNAI2 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >31 publications with SNAI2 and Neoplasm Invasiveness
 Breast Neoplasms Antibodies  >26 publications with SNAI2 and Breast Neoplasms
 Lung Neoplasms Antibodies  >20 publications with SNAI2 and Lung Neoplasms
 Lung Diseases Antibodies  >17 publications with SNAI2 and Lung Diseases
 Carcinoma, Squamous Cell Antibodies  >14 publications with SNAI2 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >12 publications with SNAI2 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >12 publications with SNAI2 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >8 publications with SNAI2 and Necrosis
 Ovarian Neoplasms Antibodies  >7 publications with SNAI2 and Ovarian Neoplasms

Organs/Tissues associated with SNAI2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >30 publications with SNAI2 and Lung
 Skin Antibodies  >21 publications with SNAI2 and Skin
 Muscle Antibodies  >15 publications with SNAI2 and Muscle
 Brain Antibodies  >12 publications with SNAI2 and Brain
 Mammary Gland Antibodies  >8 publications with SNAI2 and Mammary Gland
 Cartilage Antibodies  >3 publications with SNAI2 and Cartilage
 Pancreas Antibodies  >3 publications with SNAI2 and Pancreas
 Uterus Antibodies  >3 publications with SNAI2 and Uterus
 Adipose Tissue Antibodies  >2 publications with SNAI2 and Adipose Tissue
 Intestine Antibodies  >1 publications with SNAI2 and Intestine
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