Mouse PRLR Active Protein – Cat# MBS135828

Prolactin Receptor, Chimax Fc Fusion Protein (PRLR) Mouse Active Protein

Name: PRLR Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS135828
Price: 545 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135828

Prolactin is a neuroendocrine peptide hormone that is secreted primarily by the pituitary gland. Prolactin receptor is a class 1 cytokine transmembrane receptor that varies in size with tissue source and species. It consists of an extracellular region wit More details

$545 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Prolactin Receptor, chiMAX Fc Fusion Protein (PRLR), Active Protein

Full Product Name

Mouse Prolactin Receptor, chiMAX Fc Fusion Protein

Product Gene Name

PRLR active protein

Host

Insect cell culture

Form/Format

Lyophilized powder

Purity/Purification

>95% by SDS-PAGE analysis

Preparation and Storage

Store at -70 degree C. Shelf Life: 3 years from delivery

Molecular Weight

51,000

Chromosome Location

Chromosome: 15; NC_000081.6 (10177238..10349180). Location: 15 A1; 15 5.23 cM

3D Structure

ModBase 3D Structure for Q08501

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Specific Activity

ED50 < 10 ng/ml in the presence of 0.5 ng/ml of recombinant human prolactin as determined in a cell proliferation assay using Nb2-11 rat lymphoma cells.

Buffer

PBS

Product Categories/Family for PRLR active protein

Prolactin/Prolactin Receptor; Prolactin Receptor

Other Notes

Small volumes of PRLR active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRLR purchase

MBS135828 is an active protein targeting PRLR. Also known as Mouse Prolactin Receptor, chiMAX Fc Fusion Protein. Host: Insect cell culture.

Additional Details

NCBI/Uniprot data below describe general gene information for PRLR. It may not necessarily be applicable to this product.

NCBI GI #

359339025

NCBI GeneID

19116

NCBI Accession #

NP_001240711.1

UniProt Primary Accession #

Q08501

UniProt Secondary Accession #

P15212; P15213; Q62099

UniProt Related Accession #

Q08501

GenBank Nucleotide #

NM_001253782.2

NCBI Official Full Name

prolactin receptor isoform 3

NCBI Official Synonym Full Names

prolactin receptor

NCBI Official Symbol

Prlr

NCBI Official Synonym Symbols

Pr-1; Pr-3; AI987712; Prlr-rs1

UniProt Protein Name

Prolactin receptor

Protein Family

Prolactin receptor

UniProt Gene Name

Prlr

UniProt Synonym Gene Names

PRL-R

UniProt Entry Name

PRLR_MOUSE

NCBI Protein Information

prolactin receptor; PRL-R; prolactin receptor related sequence 1

UniProt Comments for PRLR

PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; intracellular

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; peptide hormone binding; metal ion binding; protein kinase binding; prolactin receptor activity

Biological Process: regulation of cell adhesion; lactation; transmembrane receptor protein tyrosine kinase activation (dimerization); regulation of epithelial cell differentiation; JAK-STAT cascade

Research Articles on PRLR

1. results provide direct genetic evidence that PRLR affects energy balance and metabolic adaptation in rodents via effects on brown adipose tissue differentiation and function

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PRLR active protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Growth Hormone Receptor Signaling Pathway antibodies	Growth Hormone Receptor Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with PRLR active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>109 publications with PRLR and Neoplasms
Breast Neoplasms Antibodies	>71 publications with PRLR and Breast Neoplasms
Carcinoma Antibodies	>38 publications with PRLR and Carcinoma
Mammary Neoplasms, Animal Antibodies	>16 publications with PRLR and Mammary Neoplasms, Animal
Nervous System Diseases Antibodies	>9 publications with PRLR and Nervous System Diseases
Mammary Neoplasms, Experimental Antibodies	>8 publications with PRLR and Mammary Neoplasms, Experimental
Drug Toxicity Antibodies	>8 publications with PRLR and Drug Toxicity
Liver Diseases Antibodies	>7 publications with PRLR and Liver Diseases
Necrosis Antibodies	>6 publications with PRLR and Necrosis
Weight Gain Antibodies	>6 publications with PRLR and Weight Gain

Organs/Tissues associated with PRLR active protein

Organ/Tissue Name	Pubmed Publications
Mammary Gland Antibodies	>69 publications with PRLR and Mammary Gland
Ovary Antibodies	>49 publications with PRLR and Ovary
Kidney Antibodies	>42 publications with PRLR and Kidney
Thyroid Antibodies	>4 publications with PRLR and Thyroid