PAI-1 (Wild Type Latent Form) (SERPINE1) Rat Protein

Name: SERPINE1 Protein; PAI-1 (Wild Type Latent Form); Rat; MyBioSource
Brand: MyBioSource
SKU: MBS135835
Price: 1260 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135835

Latent rat PAI-1 is a useful control for experiments when used in conjunction with the active form or stable mutant. More details

$1260 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PAI-1 (wild type latent form) (SERPINE1), Protein

Full Product Name

Rat PAI-1 (wild type latent form)

Product Gene Name

SERPINE1 protein

Host

E. coli

Form/Format

Frozen liquid

Purity/Purification

>95% by SDS-PAGE analysis

Concentration

2.5 mg/ml (lot specific)

Preparation and Storage

Store at -70 degree C. Shelf Life: 3 years from delivery

Molecular Weight

43,000

Chromosome Location

Chromosome: 12; NC_005111.3 (24653385..24663763). Location: 12q11-q12

3D Structure

ModBase 3D Structure for P20961

Buffer

0.1M HEPES; 0.1M NaCl; pH 7.4

Extinction Coefficient

Product Categories/Family for SERPINE1 protein

Plasminogen Activator Inhibitor 1 (PAI-1); Rat PAI-1

Other Notes

Small volumes of SERPINE1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINE1 purchase

MBS135835 is a protein targeting SERPINE1. Also known as Rat PAI-1 (wild type latent form). Host: E. coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINE1. It may not necessarily be applicable to this product.

NCBI GI #

6981332

NCBI GeneID

24617

NCBI Accession #

NP_036752.1

UniProt Primary Accession #

P20961

UniProt Related Accession #

P20961

GenBank Nucleotide #

NM_012620.1

NCBI Official Full Name

plasminogen activator inhibitor 1

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

NCBI Official Symbol

Serpine1

NCBI Official Synonym Symbols

Pai1; PAI1A; Planh; Pai1aa; RATPAI1A

UniProt Protein Name

Plasminogen activator inhibitor 1

UniProt Synonym Protein Names

Endothelial plasminogen activator inhibitor; Serpin E1

Protein Family

Plasminogen activator inhibitor

UniProt Gene Name

Serpine1

UniProt Synonym Gene Names

Pai1; Planh1; PAI; PAI-1

UniProt Entry Name

PAI1_RAT

NCBI Protein Information

plasminogen activator inhibitor 1; PAI; PAI-1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, member 1; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

NCBI Summary for SERPINE1

mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator; may promote neuronal survival [RGD, Feb 2006]

UniProt Comments for SERPINE1

SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protease binding; receptor binding

Biological Process: positive regulation of blood coagulation; wound healing; response to lipopolysaccharide; positive regulation of coagulation; negative regulation of smooth muscle cell migration; decidualization; defense response to Gram-negative bacterium; glucose homeostasis; mast cell activation; positive regulation of receptor-mediated endocytosis; positive regulation of interleukin-8 production; positive regulation of fibroblast proliferation; negative regulation of fibrinolysis; tissue regeneration; regulation of receptor activity; angiogenesis; chronological cell aging; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; female gonad development; positive regulation of keratinocyte migration; negative regulation of proteolysis; regulation of angiogenesis; regulation of cell proliferation; response to starvation; positive regulation of angiogenesis; response to reactive oxygen species; response to hyperoxia; cellular response to insulin stimulus; response to estrogen stimulus; response to cytokine stimulus; positive regulation of inflammatory response

Research Articles on SERPINE1

1. adhesion scores, PAI-1 activity in peritoneal lavage fluid, and PAI-1 mRNA levels in peritoneal mesothelium were significantly greater in the open surgery group than the control and laparoscopic surgery groups

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SERPINE1 protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies	BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
Blood Clotting Cascade Pathway antibodies	Blood Clotting Cascade Pathway Diagram
Brain Derived Neurotrophic Factor Pathway antibodies	Brain Derived Neurotrophic Factor Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Circadian Clock Pathway antibodies	Circadian Clock Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram

Diseases associated with SERPINE1 protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>2981 publications with SERPINE1 and Cardiovascular Diseases
Neoplasms Antibodies	>1328 publications with SERPINE1 and Neoplasms
Thrombosis Antibodies	>1295 publications with SERPINE1 and Thrombosis
Inflammation Antibodies	>1140 publications with SERPINE1 and Inflammation
Heart Diseases Antibodies	>977 publications with SERPINE1 and Heart Diseases
Necrosis Antibodies	>775 publications with SERPINE1 and Necrosis
Atherosclerosis Antibodies	>721 publications with SERPINE1 and Atherosclerosis
Hypertension Antibodies	>651 publications with SERPINE1 and Hypertension
Fibrosis Antibodies	>603 publications with SERPINE1 and Fibrosis
Myocardial Infarction Antibodies	>485 publications with SERPINE1 and Myocardial Infarction

Organs/Tissues associated with SERPINE1 protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>792 publications with SERPINE1 and Heart
Liver Antibodies	>539 publications with SERPINE1 and Liver
Connective Tissue Antibodies	>539 publications with SERPINE1 and Connective Tissue
Lung Antibodies	>511 publications with SERPINE1 and Lung
Brain Antibodies	>356 publications with SERPINE1 and Brain
Placenta Antibodies	>120 publications with SERPINE1 and Placenta
Spleen Antibodies	>22 publications with SERPINE1 and Spleen