• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1358465

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This… More details

$1530 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rho guanine nucleotide exchange factor 4 (ARHGEF4), Recombinant Protein
Full Product Name
Recombinant Human Rho guanine nucleotide exchange factor 4 (ARHGEF4)
Product Gene Name
ARHGEF4 recombinant protein
Product Synonym Gene Name
ARHGEF4
Sequence
MPWEEPAGEK PSCSHSQKAF HMEPAQKPCF TTDMVTWALL CISAETVRGE APSQPRGIPH RSPVSVDDLW LEKTQRKKLQ KQAHVERRLH IGAVHKDGVK CWRKTIITSP ESLNLPRRSH PLSQSAPTGL NHMGWPEHTP GTAMPDGALD TAVCADEVGS EEDLYDDLHS SSHHYSHPGG GGEQLAINEL ISDGSVVCAE ALWDHVTMDD QELGFKAGDV IEVMDATNRE WWWGRVADGE GWFPASFVRL RVNQDEPADD DAPLAGNSGA EDGGAEAQSS KDQMRTNVIN EILSTERDYI KHLRDICEGY VRQCRKRADM FSEEQLRTIF GNIEDIYRCQ KAFVKALEQR FNRERPHLSE LGACFLEHQA DFQIYSEYCN NHPNACVELS RLTKLSKYVY FFEACRLLQK MIDISLDGFL LTPVQKICKY PLQLAELLKY THPQHRDFKD VEAALHAMKN VAQLINERKR RLENIDKIAQ WQSSIEDWEG EDLLVRSSEL IYSGELTRVT QPQAKSQQRM FFLFDHQLIY CKKDLLRRDV LYYKGRLDMD GLEVVDLEDG KDRDLHVSIK NAFRLHRGAT GDSHLLCTRK PEQKQRWLKA FAREREQVQL DQETGFSITE LQRKQAMLNA SKQQVTGKPK AVGRPCYLTR QKHPALPSNR PQQQVLVLAE PRRKPSTFWH SISRLAPFRK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
76,420 Da
Sequence Positions
1-690, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605216
3D Structure
ModBase 3D Structure for Q9NR80
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ARHGEF4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARHGEF4 purchase

MBS1358465 is a recombinant protein targeting ARHGEF4. Also known as Recombinant Human Rho guanine nucleotide exchange factor 4 (ARHGEF4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF4. It may not necessarily be applicable to this product.

NCBI GI #
15011979
NCBI GeneID
50649
NCBI Accession #
NP_056135.2
UniProt Primary Accession #
Q9NR80
UniProt Secondary Accession #
Q9HDC6; Q9UPP0
UniProt Related Accession #
Q9NR80
GenBank Nucleotide #
NM_015320.3
NCBI Official Full Name
rho guanine nucleotide exchange factor 4 isoform a
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor 4
NCBI Official Symbol
ARHGEF4
NCBI Official Synonym Symbols
ASEF; GEF4; STM6; ASEF1
UniProt Protein Name
Rho guanine nucleotide exchange factor 4
UniProt Synonym Protein Names
APC-stimulated guanine nucleotide exchange factor 1; Asef; Asef1
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
ARHGEF4
UniProt Synonym Gene Names
KIAA1112; Asef; Asef1
NCBI Protein Information
rho guanine nucleotide exchange factor 4

NCBI Summary for ARHGEF4

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
Show more

UniProt Comments for ARHGEF4

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Show more

Research Articles on ARHGEF4

1. Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ARHGEF4 recombinant protein

 Reference Product  PubMed Publications
 APC recombinant protein  >8 publications with ARHGEF4 and APC
 SRC recombinant protein  >5 publications with ARHGEF4 and SRC
 RAC1 recombinant protein  >5 publications with ARHGEF4 and RAC1
 FAM123C recombinant protein  >1 publications with ARHGEF4 and FAM123C
 FAM168B recombinant protein  >1 publications with ARHGEF4 and FAM168B
 RHOA recombinant protein  >1 publications with ARHGEF4 and RHOA

Pathways associated with ARHGEF4 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with ARHGEF4 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with ARHGEF4 and Neoplasms
 Disease Models, Animal Antibodies  >1 publications with ARHGEF4 and Disease Models, Animal
 Nervous System Diseases Antibodies  >1 publications with ARHGEF4 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with ARHGEF4 and Brain Diseases
 Neurobehavioral Manifestations Antibodies  >1 publications with ARHGEF4 and Neurobehavioral Manifestations

Organs/Tissues associated with ARHGEF4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >3 publications with ARHGEF4 and Intestine
 Brain Antibodies  >3 publications with ARHGEF4 and Brain
 Bladder Antibodies  >1 publications with ARHGEF4 and Bladder
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000