Aryl Hydrocarbon Receptor (Ahr), Partial (AHR) Mus Musculus Castaneus Recombinant Protein

AHR: a nuclear receptor for aryl hydrocarbons involved in xenobiotic metabolism, cell cycle regulation, and development in response to both endogenous and environmental signals. AhR was initially identified as a receptor for dioxins, which are environmental pollutants generated by waste incineration and other industrial processes . AhR ligands include polycyclic aromatic hydrocarbons, including the carcinogen benzo(a)pyrene and other components of cigarette smoke. Naturally occurring AhR ligands include flavonoids, which are aromatic plant secondary compounds commonly found in vegetables and fruits. Cytoplasmic aryl hydrocarbon receptors are found in protein complexes with heat shock proteins. Upon ligand binding, AhR dissociates from heat shock proteins and translocate to the nucleus where it dimerizes with AhR nuclear translocator (ARNT, HIF-1b). The AhR/ARNT heterodimer binds to nuclear xenobiotic response elements to control the expression of genes associated with xenobiotic metabolism, including several cytochrome P450 genes. AhR is ubiquitously expressed and is thought to play a role in regulation of cell proliferation and differentiation, cytokine expression, and xenobiotic metabolism. Research studies link AhR activity with the control of regulatory T-cell and T-helper 17 cell differentiation, regulation of the inflammatory response, and the onset of lung cancer.

Protein type: DNA-binding; Transcription factor; Nuclear receptor

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein dimerization activity; protein binding; signal transducer activity; ligand-dependent nuclear receptor activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; aryl hydrocarbon receptor activity; Hsp90 protein binding; transcription factor binding; transcription factor activity

Biological Process: prostate gland development; transcription from RNA polymerase II promoter; gland development; positive regulation of cell size; blood circulation; positive regulation of transcription, DNA-dependent; response to toxin; cell morphogenesis; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to organic cyclic substance; smooth muscle development; regulation of transcription, DNA-dependent; ovarian follicle development; B cell homeostasis; post-embryonic hemopoiesis; regulation of blood pressure; response to stress; regulation of B cell proliferation; T cell homeostasis; circadian regulation of gene expression; positive regulation of transcriptional preinitiation complex assembly; regulation of blood vessel size; positive regulation of growth; spleen development; blood vessel development; camera-type eye development; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; embryonic hemopoiesis; immune system process; negative regulation of systemic arterial blood pressure; B-1 B cell homeostasis; liver development; cell cycle; negative regulation of vasoconstriction; patterning of blood vessels; regulation of transcription from RNA polymerase II promoter; response to xenobiotic stimulus; regulation of gene expression; xenobiotic metabolic process; B cell differentiation; blood vessel morphogenesis; blood vessel remodeling; negative regulation of transcription, DNA-dependent; lymphocyte homeostasis; reproductive structure development