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H/ACA Ribonucleoprotein Complex Subunit 2 (NHP2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1361462

This gene is a member of the HACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: CD and HACA. The HACA snoRNPs also include the… More details

$805 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
H/ACA ribonucleoprotein complex subunit 2 (NHP2), Recombinant Protein
Full Product Name
Recombinant Human H/ACA ribonucleoprotein complex subunit 2 (NHP2)
Product Gene Name
NHP2 recombinant protein
Product Synonym Gene Name
NHP2
Sequence
MTKIKADPDG PEAQAEACSG ERTYQELLVN QNPIAQPLAS RRLTRKLYKC IKKAVKQKQI RRGVKEVQKF VNKGEKGIMV LAGDTLPIEV YCHLPVMCED RNLPYVYIPS KTDLGAAAGS KRPTCVIMVK PHEEYQEAYD ECLEEVQSLP LPL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
17,201 Da
Sequence Positions
1-153, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606470
3D Structure
ModBase 3D Structure for Q9NX24
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NHP2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NHP2 purchase

MBS1361462 is a recombinant protein targeting NHP2. Also known as Recombinant Human H/ACA ribonucleoprotein complex subunit 2 (NHP2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NHP2. It may not necessarily be applicable to this product.

NCBI GI #
77812674
NCBI GeneID
55651
NCBI Accession #
NP_001030005.1
UniProt Primary Accession #
Q9NX24
UniProt Secondary Accession #
Q9P095; A6NKY8
UniProt Related Accession #
Q9NX24
GenBank Nucleotide #
NM_001034833.1
NCBI Official Full Name
H/ACA ribonucleoprotein complex subunit 2 isoform b
NCBI Official Synonym Full Names
NHP2 ribonucleoprotein
NCBI Official Symbol
NHP2
NCBI Official Synonym Symbols
DKCB2; NHP2P; NOLA2
UniProt Protein Name
H/ACA ribonucleoprotein complex subunit 2
UniProt Synonym Protein Names
Nucleolar protein family A member 2; snoRNP protein NHP2
Protein Family
H/ACA ribonucleoprotein complex
UniProt Gene Name
NHP2
UniProt Synonym Gene Names
NOLA2
NCBI Protein Information
H/ACA ribonucleoprotein complex subunit 2

NCBI Summary for NHP2

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
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UniProt Comments for NHP2

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
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Research Articles on NHP2

1. Indian aplastic anemia patients did not have NHP2 mutations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NHP2 recombinant protein

 Reference Product  PubMed Publications
 NOP10 recombinant protein  >39 publications with NHP2 and NOP10
 GAR1 recombinant protein  >25 publications with NHP2 and GAR1
 DKC1 recombinant protein  >23 publications with NHP2 and DKC1
 TERT recombinant protein  >17 publications with NHP2 and TERT
 NOP58 recombinant protein  >3 publications with NHP2 and NOP58
 SHQ1 recombinant protein  >1 publications with NHP2 and SHQ1

Pathways associated with NHP2 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Extension Of Telomeres Pathway antibodies  Extension Of Telomeres Pathway Diagram
 H/ACA Ribonucleoprotein Complex Pathway antibodies  H/ACA Ribonucleoprotein Complex Pathway Diagram
 H/ACA Ribonucleoprotein Complex Pathway antibodies  H/ACA Ribonucleoprotein Complex Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Telomere Extension By Telomerase Pathway antibodies  Telomere Extension By Telomerase Pathway Diagram
 Telomere Maintenance Pathway antibodies  Telomere Maintenance Pathway Diagram

Diseases associated with NHP2 recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with NHP2 and Disease Models, Animal
 Carcinoma Antibodies  >3 publications with NHP2 and Carcinoma
 Dyskeratosis Congenita, Autosomal Recessive Antibodies  >3 publications with NHP2 and Dyskeratosis Congenita, Autosomal Recessive
 Liver Neoplasms Antibodies  >2 publications with NHP2 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with NHP2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >2 publications with NHP2 and Neoplasms, Experimental
 Brain Diseases Antibodies  >2 publications with NHP2 and Brain Diseases
 Liver Failure, Acute Antibodies  >2 publications with NHP2 and Liver Failure, Acute
 Liver Neoplasms, Experimental Antibodies  >2 publications with NHP2 and Liver Neoplasms, Experimental
 Paralysis Antibodies  >1 publications with NHP2 and Paralysis

Organs/Tissues associated with NHP2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >12 publications with NHP2 and Bone
 Bone Marrow Antibodies  >12 publications with NHP2 and Bone Marrow
 Blood Antibodies  >10 publications with NHP2 and Blood
 Liver Antibodies  >7 publications with NHP2 and Liver
 Skin Antibodies  >5 publications with NHP2 and Skin
 Lung Antibodies  >5 publications with NHP2 and Lung
 Eye Antibodies  >3 publications with NHP2 and Eye
 Heart Antibodies  >3 publications with NHP2 and Heart
 Brain Antibodies  >3 publications with NHP2 and Brain
 Prostate Antibodies  >2 publications with NHP2 and Prostate
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