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Deoxyribonuclease-1 (DNASE1) Dog Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1361535

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1… More details

$945 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Deoxyribonuclease-1 (DNASE1), Recombinant Protein
Full Product Name
Recombinant Dog Deoxyribonuclease-1 (DNASE1)
Product Gene Name
DNASE1 recombinant protein
Product Synonym Gene Name
DNASE1
Sequence
LRMAAFNIRT FGETKMSNAT LSKYIVQILS RYDVAVVQEV RDSHLTAVGK LLDTLNQDDP NAYHYVVSEP LGRSSYKERY LFLFRPDRVS VLDSYQYDDG CEPCGNDTFS REPAIVRFHS PLTEVKEFAV VPLHAAPLDA VAEIDALYDV YLDVQHKWDL EDIVLMGDFN AGCSYVAASQ WSSIRLRTNP AFQWLIPDTA DTTSTSTHCA YDRIVVAGSQ LQHAVVPESA APFNFQVAYG LSSQLAQAIS DHYPVEVTLK RA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
31,485 Da
Sequence Positions
23-284, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q767J3
Species
Canis familiaris (Dog) (Canis lupus familiaris)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DNASE1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNASE1 purchase

MBS1361535 is a recombinant protein targeting DNASE1. Also known as Recombinant Dog Deoxyribonuclease-1 (DNASE1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for DNASE1. It may not necessarily be applicable to this product.

NCBI GI #
50950149
NCBI GeneID
403413
NCBI Accession #
NP_001002946.1
UniProt Primary Accession #
Q767J3
UniProt Related Accession #
Q767J3
GenBank Nucleotide #
NM_001002946.1
NCBI Official Full Name
deoxyribonuclease-1
NCBI Official Synonym Full Names
deoxyribonuclease 1
NCBI Official Symbol
DNASE1
UniProt Protein Name
Deoxyribonuclease-1
UniProt Synonym Protein Names
Deoxyribonuclease I; DNase I
Protein Family
Deoxyribonuclease
UniProt Gene Name
DNASE1
UniProt Synonym Gene Names
DNase I
NCBI Protein Information
deoxyribonuclease-1

UniProt Comments for DNASE1

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:14688237). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (). Among other functions, seems to be involved in cell death by apoptosis (PubMed:14688237). Binds specifically to G-actin and blocks actin polymerization (PubMed:14688237). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation ().
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Research Articles on DNASE1

1. canine enzyme is more closely related to the human DNase I than to other mammalian DNases I

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with DNASE1 recombinant protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >219 publications with DNASE1 and Fibrosis
 Lupus Erythematosus, Systemic Antibodies  >27 publications with DNASE1 and Lupus Erythematosus, Systemic
 Inflammation Antibodies  >25 publications with DNASE1 and Inflammation
 Kidney Diseases Antibodies  >12 publications with DNASE1 and Kidney Diseases
 Necrosis Antibodies  >8 publications with DNASE1 and Necrosis
 Heart Defects, Congenital Antibodies  >6 publications with DNASE1 and Heart Defects, Congenital
 Proteinuria Antibodies  >4 publications with DNASE1 and Proteinuria
 Drug-Induced Liver Injury Antibodies  >3 publications with DNASE1 and Drug-Induced Liver Injury
 Liver Diseases Antibodies  >3 publications with DNASE1 and Liver Diseases
 Pain Antibodies  >3 publications with DNASE1 and Pain

Organs/Tissues associated with DNASE1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >15 publications with DNASE1 and Kidney
 Liver Antibodies  >10 publications with DNASE1 and Liver
 Mixed Antibodies  >8 publications with DNASE1 and Mixed
 Pancreas Antibodies  >3 publications with DNASE1 and Pancreas
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