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Peptidyl-Prolyl Cis-Trans Isomerase FKBP5 (FKBP5) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1362214

This protein is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the… More details

$1230 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5), Recombinant Protein
Full Product Name
Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)
Product Gene Name
FKBP5 recombinant protein
Product Synonym Gene Name
FKBP5
Sequence
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
30,032 Da
Sequence Positions
1-457, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
602623
3D Structure
ModBase 3D Structure for Q13451
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FKBP5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP5 purchase

MBS1362214 is a recombinant protein targeting FKBP5. Also known as Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP5. It may not necessarily be applicable to this product.

NCBI GI #
224809327
NCBI GeneID
2289
NCBI Accession #
NP_001139247.1
UniProt Primary Accession #
Q13451
UniProt Secondary Accession #
Q59EB8; Q5TGM6; F5H7R1
UniProt Related Accession #
Q13451
GenBank Nucleotide #
NM_001145775.2
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1
NCBI Official Synonym Full Names
FK506 binding protein 5
NCBI Official Symbol
FKBP5
NCBI Official Synonym Symbols
P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP5
UniProt Synonym Protein Names
51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase
Protein Family
FK506-binding protein
UniProt Gene Name
FKBP5
UniProt Synonym Gene Names
AIG6; FKBP51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5; p54
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP5

NCBI Summary for FKBP5

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
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UniProt Comments for FKBP5

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.
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Research Articles on FKBP5

1. Children with high attachment insecurity and homozygous FKBP5 minor alleles manifest maladaptive emotion regulation and depressive symptoms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKBP5 recombinant protein

 Reference Product  PubMed Publications
 FKBP4 recombinant protein  >16 publications with FKBP5 and FKBP4
 SERPINB2 recombinant protein  >1 publications with FKBP5 and SERPINB2
 AKT1 recombinant protein  >1 publications with FKBP5 and AKT1
 HSP90AA1 recombinant protein  >1 publications with FKBP5 and HSP90AA1

Pathways associated with FKBP5 recombinant protein

 Products by Pathway  Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with FKBP5 recombinant protein

 Disease Name  Pubmed Publications
 Depressive Disorder, Major Antibodies  >30 publications with FKBP5 and Depressive Disorder, Major
 Nervous System Diseases Antibodies  >12 publications with FKBP5 and Nervous System Diseases
 Inflammation Antibodies  >9 publications with FKBP5 and Inflammation
 Neoplasms, Experimental Antibodies  >8 publications with FKBP5 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >7 publications with FKBP5 and Disease Models, Animal
 Necrosis Antibodies  >6 publications with FKBP5 and Necrosis
 Brain Diseases Antibodies  >6 publications with FKBP5 and Brain Diseases
 Hypertension Antibodies  >5 publications with FKBP5 and Hypertension
 Hyperplasia Antibodies  >4 publications with FKBP5 and Hyperplasia
 Learning Disorders Antibodies  >4 publications with FKBP5 and Learning Disorders

Organs/Tissues associated with FKBP5 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >84 publications with FKBP5 and Brain
 Blood Antibodies  >56 publications with FKBP5 and Blood
 Prostate Antibodies  >17 publications with FKBP5 and Prostate
 Kidney Antibodies  >8 publications with FKBP5 and Kidney
 Heart Antibodies  >7 publications with FKBP5 and Heart
 Muscle Antibodies  >5 publications with FKBP5 and Muscle
 Intestine Antibodies  >4 publications with FKBP5 and Intestine
 Liver Antibodies  >3 publications with FKBP5 and Liver
 Bone Marrow Antibodies  >3 publications with FKBP5 and Bone Marrow
 Uterus Antibodies  >3 publications with FKBP5 and Uterus
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